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Nematophilic bacteria associated with entomopathogenic nematodes and drug development of their biomolecules
The importance of Xenorhabdus and Photorhabdus symbionts to their respective Steinernema and Heterorhabditis nematode hosts is that they not only contribute to their entomopathogenicity but also to their fecundity through the production of small molecules. Thus, this mini-review gives a brief introd...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9520725/ https://www.ncbi.nlm.nih.gov/pubmed/36187939 http://dx.doi.org/10.3389/fmicb.2022.993688 |
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author | Awori, Ryan Musumba |
author_facet | Awori, Ryan Musumba |
author_sort | Awori, Ryan Musumba |
collection | PubMed |
description | The importance of Xenorhabdus and Photorhabdus symbionts to their respective Steinernema and Heterorhabditis nematode hosts is that they not only contribute to their entomopathogenicity but also to their fecundity through the production of small molecules. Thus, this mini-review gives a brief introductory overview of these nematophilic bacteria. Specifically, their type species, nematode hosts, and geographic region of isolations are tabulated. The use of nucleotide sequence-based techniques for their species delineation and how pangenomes can improve this are highlighted. Using the Steinernema–Xenorhabdus association as an example, the bacterium-nematode lifecycle is visualized with an emphasis on the role of bacterial biomolecules. Those currently in drug development are discussed, and two potential antimalarial lead compounds are highlighted. Thus, this mini-review tabulates forty-eight significant nematophilic bacteria and visualizes the ecological importance of their biomolecules. It further discusses three of these biomolecules that are currently in drug development. Through it, one is introduced to Xenorhabdus and Photorhabdus bacteria, their natural production of biomolecules in the nematode-bacterium lifecycle, and how these molecules are useful in developing novel therapies. |
format | Online Article Text |
id | pubmed-9520725 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95207252022-09-30 Nematophilic bacteria associated with entomopathogenic nematodes and drug development of their biomolecules Awori, Ryan Musumba Front Microbiol Microbiology The importance of Xenorhabdus and Photorhabdus symbionts to their respective Steinernema and Heterorhabditis nematode hosts is that they not only contribute to their entomopathogenicity but also to their fecundity through the production of small molecules. Thus, this mini-review gives a brief introductory overview of these nematophilic bacteria. Specifically, their type species, nematode hosts, and geographic region of isolations are tabulated. The use of nucleotide sequence-based techniques for their species delineation and how pangenomes can improve this are highlighted. Using the Steinernema–Xenorhabdus association as an example, the bacterium-nematode lifecycle is visualized with an emphasis on the role of bacterial biomolecules. Those currently in drug development are discussed, and two potential antimalarial lead compounds are highlighted. Thus, this mini-review tabulates forty-eight significant nematophilic bacteria and visualizes the ecological importance of their biomolecules. It further discusses three of these biomolecules that are currently in drug development. Through it, one is introduced to Xenorhabdus and Photorhabdus bacteria, their natural production of biomolecules in the nematode-bacterium lifecycle, and how these molecules are useful in developing novel therapies. Frontiers Media S.A. 2022-09-15 /pmc/articles/PMC9520725/ /pubmed/36187939 http://dx.doi.org/10.3389/fmicb.2022.993688 Text en Copyright © 2022 Awori. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Microbiology Awori, Ryan Musumba Nematophilic bacteria associated with entomopathogenic nematodes and drug development of their biomolecules |
title | Nematophilic bacteria associated with entomopathogenic nematodes and drug development of their biomolecules |
title_full | Nematophilic bacteria associated with entomopathogenic nematodes and drug development of their biomolecules |
title_fullStr | Nematophilic bacteria associated with entomopathogenic nematodes and drug development of their biomolecules |
title_full_unstemmed | Nematophilic bacteria associated with entomopathogenic nematodes and drug development of their biomolecules |
title_short | Nematophilic bacteria associated with entomopathogenic nematodes and drug development of their biomolecules |
title_sort | nematophilic bacteria associated with entomopathogenic nematodes and drug development of their biomolecules |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9520725/ https://www.ncbi.nlm.nih.gov/pubmed/36187939 http://dx.doi.org/10.3389/fmicb.2022.993688 |
work_keys_str_mv | AT aworiryanmusumba nematophilicbacteriaassociatedwithentomopathogenicnematodesanddrugdevelopmentoftheirbiomolecules |