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Atheroprone fluid shear stress-regulated ALK1-Endoglin-SMAD signaling originates from early endosomes

BACKGROUND: Fluid shear stress enhances endothelial SMAD1/5 signaling via the BMP9-bound ALK1 receptor complex supported by the co-receptor Endoglin. While moderate SMAD1/5 activation is required to maintain endothelial quiescence, excessive SMAD1/5 signaling promotes endothelial dysfunction. Increa...

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Detalles Bibliográficos
Autores principales:	Mendez, Paul-Lennard, Obendorf, Leon, Jatzlau, Jerome, Burdzinski, Wiktor, Reichenbach, Maria, Nageswaran, Vanasa, Haghikia, Arash, Stangl, Verena, Hiepen, Christian, Knaus, Petra
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9520843/ https://www.ncbi.nlm.nih.gov/pubmed/36171573 http://dx.doi.org/10.1186/s12915-022-01396-y

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