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Association between plasma cadmium and renal stone prevalence in adults in rural areas of Guangxi, China: a case–control study
BACKGROUND: Kidney stones have become a worldwide public health problem. The purpose of this research is to study the relationship between plasma cadmium level and the prevalence of kidney stones in an adult population. METHODS: The data of this study were based on a current survey conducted from De...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9520925/ https://www.ncbi.nlm.nih.gov/pubmed/36171551 http://dx.doi.org/10.1186/s12882-022-02945-x |
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author | Li, You He, Kailian Cao, Liang Tang, Xu Gou, Ruoyu Luo, Tingyu Xiao, Song Chen, Ziqi Li, Tingjun Qin, Jian Zhang, Zhiyong Cai, Jiansheng |
author_facet | Li, You He, Kailian Cao, Liang Tang, Xu Gou, Ruoyu Luo, Tingyu Xiao, Song Chen, Ziqi Li, Tingjun Qin, Jian Zhang, Zhiyong Cai, Jiansheng |
author_sort | Li, You |
collection | PubMed |
description | BACKGROUND: Kidney stones have become a worldwide public health problem. The purpose of this research is to study the relationship between plasma cadmium level and the prevalence of kidney stones in an adult population. METHODS: The data of this study were based on a current survey conducted from December 2018 to November 2019 in Gongcheng Yao Autonomous County, Guangxi, China. A total of 940 study subjects of the same sex and age (within 2 years of each other) according to 1:1 matching were selected for a case–control study. The diagnosis of kidney stones was based on the presence of strong light spots, patches, clusters, or bands within the renal sinus region, followed by an echo-free bundle of acoustic images. Plasma metal elements were determined by the metal plasma method. The relationship between plasma cadmium concentration and the prevalence of kidney stones was assessed using logistic regression and restricted cubic spline regression. RESULTS: The crude ratio for kidney stones in the highest quartile of plasma cadmium was 1.164 (95% CI, 1.121 to 2.324) compared with the lowest quartile. A positive correlation was found between the two (P for trend = 0.039). After adjusting for potential confounders, the ratio of plasma cadmium to kidney stones in the highest quartile was 1.606 (95% CI, 1.100 to 2.344) compared with the lowest quartile, and the findings remained unchanged. CONCLUSION: The odds of kidney stones in adults increased with increasing plasma cadmium exposure, and high plasma cadmium may be a risk factor for kidney stones. |
format | Online Article Text |
id | pubmed-9520925 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-95209252022-09-30 Association between plasma cadmium and renal stone prevalence in adults in rural areas of Guangxi, China: a case–control study Li, You He, Kailian Cao, Liang Tang, Xu Gou, Ruoyu Luo, Tingyu Xiao, Song Chen, Ziqi Li, Tingjun Qin, Jian Zhang, Zhiyong Cai, Jiansheng BMC Nephrol Research BACKGROUND: Kidney stones have become a worldwide public health problem. The purpose of this research is to study the relationship between plasma cadmium level and the prevalence of kidney stones in an adult population. METHODS: The data of this study were based on a current survey conducted from December 2018 to November 2019 in Gongcheng Yao Autonomous County, Guangxi, China. A total of 940 study subjects of the same sex and age (within 2 years of each other) according to 1:1 matching were selected for a case–control study. The diagnosis of kidney stones was based on the presence of strong light spots, patches, clusters, or bands within the renal sinus region, followed by an echo-free bundle of acoustic images. Plasma metal elements were determined by the metal plasma method. The relationship between plasma cadmium concentration and the prevalence of kidney stones was assessed using logistic regression and restricted cubic spline regression. RESULTS: The crude ratio for kidney stones in the highest quartile of plasma cadmium was 1.164 (95% CI, 1.121 to 2.324) compared with the lowest quartile. A positive correlation was found between the two (P for trend = 0.039). After adjusting for potential confounders, the ratio of plasma cadmium to kidney stones in the highest quartile was 1.606 (95% CI, 1.100 to 2.344) compared with the lowest quartile, and the findings remained unchanged. CONCLUSION: The odds of kidney stones in adults increased with increasing plasma cadmium exposure, and high plasma cadmium may be a risk factor for kidney stones. BioMed Central 2022-09-28 /pmc/articles/PMC9520925/ /pubmed/36171551 http://dx.doi.org/10.1186/s12882-022-02945-x Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Li, You He, Kailian Cao, Liang Tang, Xu Gou, Ruoyu Luo, Tingyu Xiao, Song Chen, Ziqi Li, Tingjun Qin, Jian Zhang, Zhiyong Cai, Jiansheng Association between plasma cadmium and renal stone prevalence in adults in rural areas of Guangxi, China: a case–control study |
title | Association between plasma cadmium and renal stone prevalence in adults in rural areas of Guangxi, China: a case–control study |
title_full | Association between plasma cadmium and renal stone prevalence in adults in rural areas of Guangxi, China: a case–control study |
title_fullStr | Association between plasma cadmium and renal stone prevalence in adults in rural areas of Guangxi, China: a case–control study |
title_full_unstemmed | Association between plasma cadmium and renal stone prevalence in adults in rural areas of Guangxi, China: a case–control study |
title_short | Association between plasma cadmium and renal stone prevalence in adults in rural areas of Guangxi, China: a case–control study |
title_sort | association between plasma cadmium and renal stone prevalence in adults in rural areas of guangxi, china: a case–control study |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9520925/ https://www.ncbi.nlm.nih.gov/pubmed/36171551 http://dx.doi.org/10.1186/s12882-022-02945-x |
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