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Characteristics and prognosis of primary pulmonary osteosarcoma: a pooled analysis
BACKGROUND: Primary pulmonary osteosarcoma (PPOS) is an uncommon malignancy originating from the lung with low incidence, and its clinical characteristics and prognosis have not been systematically reported. Therefore, we aimed to recognize the prognostic factors and constructed a survival predictio...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9520935/ https://www.ncbi.nlm.nih.gov/pubmed/36171612 http://dx.doi.org/10.1186/s13019-022-02010-6 |
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author | Huang, Weijia Deng, Han-Yu Li, Deyan Li, Peiwei Xu, Kai Zhang, Yu-Xiao Weng, Jia-Hui Zhou, Qinghua |
author_facet | Huang, Weijia Deng, Han-Yu Li, Deyan Li, Peiwei Xu, Kai Zhang, Yu-Xiao Weng, Jia-Hui Zhou, Qinghua |
author_sort | Huang, Weijia |
collection | PubMed |
description | BACKGROUND: Primary pulmonary osteosarcoma (PPOS) is an uncommon malignancy originating from the lung with low incidence, and its clinical characteristics and prognosis have not been systematically reported. Therefore, we aimed to recognize the prognostic factors and constructed a survival prediction model for PPOS. METHODS: We collected the data from the Surveillance, Epidemiology, and End Results database and systematic review of previous studies. Demographical and clinical characteristics, radiographic manifestations, treatment modalities, and prognosis were analyzed. A prediction model via nomogram was constructed and then evaluated by the concordance index (C-index) and the receiver operating characteristic (ROC) curve. RESULTS: A total of 49 cases were included for analysis with a median age of 67 years old (range 33–94 years), of which 32 (65.3%) were male. The median size was 6 cm (range 1.8-25 cm), and the median overall survival (OS) was eight months (interquartile range 4.5–12 months) with a 1-year OS rate of 30.8%. Tumor size over 7 cm (hazard ratio [HR] = 2.98; P = 0.018) and those without microscopic findings of osteoid found in the tumors (HR = 2.11; P = 0.048) were referred to a poor OS, while surgery was associated with an improved OS (HR = 0.20; P < 0.001). The C-index of the nomogram prediction model was 0.771, and the area under curve, sensitivity and specificity of the ROC curve were 0.818, 0.848 and 0.800, respectively. CONCLUSIONS: Patients with PPOS had a poor prognosis, and tumor size was mostly prognostic. Surgery seemed to be an effective treatment, and the prediction model with a nomogram in our study could effectively predict the prognosis of patients with PPOS. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13019-022-02010-6. |
format | Online Article Text |
id | pubmed-9520935 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-95209352022-09-30 Characteristics and prognosis of primary pulmonary osteosarcoma: a pooled analysis Huang, Weijia Deng, Han-Yu Li, Deyan Li, Peiwei Xu, Kai Zhang, Yu-Xiao Weng, Jia-Hui Zhou, Qinghua J Cardiothorac Surg Research Article BACKGROUND: Primary pulmonary osteosarcoma (PPOS) is an uncommon malignancy originating from the lung with low incidence, and its clinical characteristics and prognosis have not been systematically reported. Therefore, we aimed to recognize the prognostic factors and constructed a survival prediction model for PPOS. METHODS: We collected the data from the Surveillance, Epidemiology, and End Results database and systematic review of previous studies. Demographical and clinical characteristics, radiographic manifestations, treatment modalities, and prognosis were analyzed. A prediction model via nomogram was constructed and then evaluated by the concordance index (C-index) and the receiver operating characteristic (ROC) curve. RESULTS: A total of 49 cases were included for analysis with a median age of 67 years old (range 33–94 years), of which 32 (65.3%) were male. The median size was 6 cm (range 1.8-25 cm), and the median overall survival (OS) was eight months (interquartile range 4.5–12 months) with a 1-year OS rate of 30.8%. Tumor size over 7 cm (hazard ratio [HR] = 2.98; P = 0.018) and those without microscopic findings of osteoid found in the tumors (HR = 2.11; P = 0.048) were referred to a poor OS, while surgery was associated with an improved OS (HR = 0.20; P < 0.001). The C-index of the nomogram prediction model was 0.771, and the area under curve, sensitivity and specificity of the ROC curve were 0.818, 0.848 and 0.800, respectively. CONCLUSIONS: Patients with PPOS had a poor prognosis, and tumor size was mostly prognostic. Surgery seemed to be an effective treatment, and the prediction model with a nomogram in our study could effectively predict the prognosis of patients with PPOS. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13019-022-02010-6. BioMed Central 2022-09-29 /pmc/articles/PMC9520935/ /pubmed/36171612 http://dx.doi.org/10.1186/s13019-022-02010-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Huang, Weijia Deng, Han-Yu Li, Deyan Li, Peiwei Xu, Kai Zhang, Yu-Xiao Weng, Jia-Hui Zhou, Qinghua Characteristics and prognosis of primary pulmonary osteosarcoma: a pooled analysis |
title | Characteristics and prognosis of primary pulmonary osteosarcoma: a pooled analysis |
title_full | Characteristics and prognosis of primary pulmonary osteosarcoma: a pooled analysis |
title_fullStr | Characteristics and prognosis of primary pulmonary osteosarcoma: a pooled analysis |
title_full_unstemmed | Characteristics and prognosis of primary pulmonary osteosarcoma: a pooled analysis |
title_short | Characteristics and prognosis of primary pulmonary osteosarcoma: a pooled analysis |
title_sort | characteristics and prognosis of primary pulmonary osteosarcoma: a pooled analysis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9520935/ https://www.ncbi.nlm.nih.gov/pubmed/36171612 http://dx.doi.org/10.1186/s13019-022-02010-6 |
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