Lengthening the Guanidine–Aryl Linker of Phenylpyrimidinylguanidines Increases Their Potency as Inhibitors of FOXO3-Induced Gene Transcription

[Image: see text] Increased FOXO3 nuclear localization is involved in neuroblastoma chemoresistance and tumor angiogenesis. Accordingly, FOXO3 inhibition is a promising strategy for boosting antitumor immune responses and suppressing FOXO3-mediated therapy resistance in cancer cells. However, no FOX...

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Detalles Bibliográficos
Autores principales: Kohoutova, Klara, Dočekal, Vojtěch, Ausserlechner, Michael J., Kaiser, Nora, Tekel, Andrej, Mandal, Raju, Horvath, Matej, Obsilova, Veronika, Vesely, Jan, Hagenbuchner, Judith, Obsil, Tomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9521028/
https://www.ncbi.nlm.nih.gov/pubmed/36188303
http://dx.doi.org/10.1021/acsomega.2c04613

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9521028/
https://www.ncbi.nlm.nih.gov/pubmed/36188303
http://dx.doi.org/10.1021/acsomega.2c04613

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