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Mulberry leaf polyphenols alleviated high-fat diet-induced obesity in mice
Mulberry leaf is an important medicinal food plant, which is rich in polyphenol compounds. Mulberry leaf polyphenols (MLP) possess significant lipid-lowering and antioxidant effects, and healthcare functions. In this study, the polyphenol content of mulberry leaf ethanol extract was measured using H...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9521161/ https://www.ncbi.nlm.nih.gov/pubmed/36185673 http://dx.doi.org/10.3389/fnut.2022.979058 |
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author | Li, Rui Zhu, Qubo Wang, Xiaoyan Wang, Haiyan |
author_facet | Li, Rui Zhu, Qubo Wang, Xiaoyan Wang, Haiyan |
author_sort | Li, Rui |
collection | PubMed |
description | Mulberry leaf is an important medicinal food plant, which is rich in polyphenol compounds. Mulberry leaf polyphenols (MLP) possess significant lipid-lowering and antioxidant effects, and healthcare functions. In this study, the polyphenol content of mulberry leaf ethanol extract was measured using HPLC. The analysis of mulberry leaf extract resulted in the identification of 14 compounds, of which Chlorogenic acid and Quercitrin were the highest. A high-fat diet (HFD)-induced obese mouse model was developed and treated with MLP for 12 weeks to explore their effect on lipid metabolism in HFD-induced obese mice. The results showed that the MLP could inhibit the weight gain and fat cell volume increase in the HFD-induced obese mice in a dose-dependent manner. Further analysis revealed that the MLP decelerated the fatty acid composition in the adipose tissues of HFD-induced obese mice, and significantly increased the polyunsaturated-to-saturated fatty acid (PUFA/SFA) ratio. The real-time quantitative PCR (RT-qPCR) results indicated that the MLP significantly inhibited the down regulation of uncoupling protein (UCP) 1 (UCP1), UCP3, and PR domain zinc finger protein 16 (PRDM16) caused by the HFD. These beneficial effects of MLP on HFD-induced obese mice might be attributed to their ability to change the fatty acid composition of adipose tissue and increase the expression of thermogenesis genes. Overall, the study results suggested that the MLP could serve as potential lipid-lowering and weight-loss functional food and healthcare products. |
format | Online Article Text |
id | pubmed-9521161 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95211612022-09-30 Mulberry leaf polyphenols alleviated high-fat diet-induced obesity in mice Li, Rui Zhu, Qubo Wang, Xiaoyan Wang, Haiyan Front Nutr Nutrition Mulberry leaf is an important medicinal food plant, which is rich in polyphenol compounds. Mulberry leaf polyphenols (MLP) possess significant lipid-lowering and antioxidant effects, and healthcare functions. In this study, the polyphenol content of mulberry leaf ethanol extract was measured using HPLC. The analysis of mulberry leaf extract resulted in the identification of 14 compounds, of which Chlorogenic acid and Quercitrin were the highest. A high-fat diet (HFD)-induced obese mouse model was developed and treated with MLP for 12 weeks to explore their effect on lipid metabolism in HFD-induced obese mice. The results showed that the MLP could inhibit the weight gain and fat cell volume increase in the HFD-induced obese mice in a dose-dependent manner. Further analysis revealed that the MLP decelerated the fatty acid composition in the adipose tissues of HFD-induced obese mice, and significantly increased the polyunsaturated-to-saturated fatty acid (PUFA/SFA) ratio. The real-time quantitative PCR (RT-qPCR) results indicated that the MLP significantly inhibited the down regulation of uncoupling protein (UCP) 1 (UCP1), UCP3, and PR domain zinc finger protein 16 (PRDM16) caused by the HFD. These beneficial effects of MLP on HFD-induced obese mice might be attributed to their ability to change the fatty acid composition of adipose tissue and increase the expression of thermogenesis genes. Overall, the study results suggested that the MLP could serve as potential lipid-lowering and weight-loss functional food and healthcare products. Frontiers Media S.A. 2022-09-15 /pmc/articles/PMC9521161/ /pubmed/36185673 http://dx.doi.org/10.3389/fnut.2022.979058 Text en Copyright © 2022 Li, Zhu, Wang and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Nutrition Li, Rui Zhu, Qubo Wang, Xiaoyan Wang, Haiyan Mulberry leaf polyphenols alleviated high-fat diet-induced obesity in mice |
title | Mulberry leaf polyphenols alleviated high-fat diet-induced obesity in mice |
title_full | Mulberry leaf polyphenols alleviated high-fat diet-induced obesity in mice |
title_fullStr | Mulberry leaf polyphenols alleviated high-fat diet-induced obesity in mice |
title_full_unstemmed | Mulberry leaf polyphenols alleviated high-fat diet-induced obesity in mice |
title_short | Mulberry leaf polyphenols alleviated high-fat diet-induced obesity in mice |
title_sort | mulberry leaf polyphenols alleviated high-fat diet-induced obesity in mice |
topic | Nutrition |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9521161/ https://www.ncbi.nlm.nih.gov/pubmed/36185673 http://dx.doi.org/10.3389/fnut.2022.979058 |
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