Cargando…

An engineered concealed IL-15-R elicits tumor-specific CD8(+)T cell responses through PD-1-cis delivery

Checkpoint blockade immunotherapy releases the inhibition of tumor-infiltrating lymphocytes (TILs) but weakly induces TIL proliferation. Exogenous IL-15 could further expand TILs and thus synergize with αPD-L1 therapy. However, systemic delivery of IL-15 extensively expands peripheral NK cells, caus...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shen, Jiao, Zou, Zhuangzhi, Guo, Jingya, Cai, Yueqi, Xue, Diyuan, Liang, Yong, Wang, Wenyan, Peng, Hua, Fu, Yang-Xin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2022
Materias:	Brief Definitive Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9521244/ https://www.ncbi.nlm.nih.gov/pubmed/36165896 http://dx.doi.org/10.1084/jem.20220745

Ejemplares similares

Intratumoral IL-12 combined with CTLA-4 blockade elicits T cell–mediated glioma rejection
por: vom Berg, Johannes, et al.
Publicado: (2013)

IL-15 trans-presentation promotes human NK cell development and differentiation in vivo
por: Huntington, Nicholas D., et al.
Publicado: (2009)

IL-7 and IL-15 independently program the differentiation of intestinal CD3(−)NKp46(+) cell subsets from Id2-dependent precursors
por: Satoh-Takayama, Naoko, et al.
Publicado: (2010)

The Involvement of Interleukin (IL)-15 in Regulating the Differentiation of Granulated Metrial Gland Cells in Mouse Pregnant Uterus
por: Ye, Weiguo, et al.
Publicado: (1996)

Gata2 cis-element is required for hematopoietic stem cell generation in the mammalian embryo
por: Gao, Xin, et al.
Publicado: (2013)

Neutrophils are required for both the sensitization and elicitation phase of contact hypersensitivity
por: Weber, Felix C., et al.
Publicado: (2015)

Cysteinyl leukotrienes mediate lymphokine killer activity induced by NKG2D and IL-15 in cytotoxic T cells during celiac disease
por: Tang, Fangming, et al.
Publicado: (2015)

Genetic manipulation of LKB1 elicits lethal metastatic prostate cancer
por: Hermanova, Ivana, et al.
Publicado: (2020)

Commensal-dependent expression of IL-25 regulates the IL-23–IL-17 axis in the intestine
por: Zaph, Colby, et al.
Publicado: (2008)

Interleukin (IL)-4 inhibits IL-10 to promote IL-12 production by dendritic cells
por: Yao, Yongxue, et al.
Publicado: (2005)

Divergent Pro- and Antiinflammatory Roles for IL-23 and IL-12 in Joint Autoimmune Inflammation
por: Murphy, Craig A., et al.
Publicado: (2003)

Lymphoid tissue inducer–like cells are an innate source of IL-17 and IL-22
por: Takatori, Hiroaki, et al.
Publicado: (2009)

Autoantibodies against IL-17A, IL-17F, and IL-22 in patients with chronic mucocutaneous candidiasis and autoimmune polyendocrine syndrome type I
por: Puel, Anne, et al.
Publicado: (2010)

IL-31–IL-31R interactions negatively regulate type 2 inflammation in the lung
por: Perrigoue, Jacqueline G., et al.
Publicado: (2007)

Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells
por: Seddiki, Nabila, et al.
Publicado: (2006)

The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4(+) T cells
por: Dienz, Oliver, et al.
Publicado: (2009)

IL-17 can promote tumor growth through an IL-6–Stat3 signaling pathway
por: Wang, Lin, et al.
Publicado: (2009)

IL-33 reduces the development of atherosclerosis
por: Miller, Ashley M., et al.
Publicado: (2008)

Mutations in STAT3 and IL12RB1 impair the development of human IL-17–producing T cells
por: de Beaucoudrey, Ludovic, et al.
Publicado: (2008)

IL-6–dependent spontaneous proliferation is required for the induction of colitogenic IL-17–producing CD8(+) T cells
por: Tajima, Masaki, et al.
Publicado: (2008)

Blimp-1 directly represses Il2 and the Il2 activator Fos, attenuating T cell proliferation and survival
por: Martins, Gislâine A., et al.
Publicado: (2008)

Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides
por: Liang, Spencer C., et al.
Publicado: (2006)

A crucial role for interleukin (IL)-1 in the induction of IL-17–producing T cells that mediate autoimmune encephalomyelitis
por: Sutton, Caroline, et al.
Publicado: (2006)

Microbiota-induced IL-1β, but not IL-6, is critical for the development of steady-state T(H)17 cells in the intestine
por: Shaw, Michael H., et al.
Publicado: (2012)

Interleukin (IL)-4–independent Induction of Immunoglobulin (Ig)E, and Perturbation of T Cell Development in Transgenic Mice Expressing IL-13
por: Emson, Claire L., et al.
Publicado: (1998)

A novel subset of mouse NKT cells bearing the IL-17 receptor B responds to IL-25 and contributes to airway hyperreactivity
por: Terashima, Asuka, et al.
Publicado: (2008)

A late IL-33 response after exposure to Schistosoma haematobium antigen is associated with an up-regulation of IL-13 in human eosinophils
por: Wilson, S, et al.
Publicado: (2013)

IL-12– and IL-23–modulated T cells induce distinct types of EAE based on histology, CNS chemokine profile, and response to cytokine inhibition
por: Kroenke, Mark A., et al.
Publicado: (2008)

Murine Macrophages Secrete Interferon γ upon Combined Stimulation with Interleukin (IL)-12 and IL-18: A Novel Pathway of Autocrine Macrophage Activation
por: Munder, Markus, et al.
Publicado: (1998)

Facilitation of β Selection and Modification of Positive Selection in the Thymus of Pd-1–Deficient Mice
por: Nishimura, Hiroyuki, et al.
Publicado: (2000)

In Vivo Cytotoxic T Lymphocyte Elicitation by Mycobacterial Heat Shock Protein 70 Fusion Proteins Maps to a Discrete Domain and Is Cd4(+) T Cell Independent
por: Huang, Qian, et al.
Publicado: (2000)

IL-17 produced by Paneth cells drives TNF-induced shock
por: Takahashi, Nozomi, et al.
Publicado: (2008)

Role of IL-17 and regulatory T lymphocytes in a systemic autoimmune disease
por: Lohr, Jens, et al.
Publicado: (2006)

NF90 regulates inducible IL-2 gene expression in T cells
por: Shi, Lingfang, et al.
Publicado: (2007)

IL-9 as a mediator of Th17-driven inflammatory disease
por: Nowak, Elizabeth C., et al.
Publicado: (2009)

PD-1 blockade and CDK4/6 inhibition augment nonoverlapping features of T cell activation in cancer
por: Ali, Lestat R., et al.
Publicado: (2023)

Interleukin 15 Skews Monocyte Differentiation into Dendritic Cells with Features of Langerhans Cells
por: Mohamadzadeh, Mansour, et al.
Publicado: (2001)

T Cell–Independent Interleukin 15rα Signals Are Required for Bystander Proliferation
por: Lodolce, James P., et al.
Publicado: (2001)

Trav15-dv6 family Tcrd rearrangements diversify the Tcra repertoire
por: Dauphars, Danielle J., et al.
Publicado: (2021)

Prevention of UV radiation–induced immunosuppression by IL-12 is dependent on DNA repair
por: Schwarz, Agatha, et al.
Publicado: (2005)

Cannot write session to /tmp/vufind_sessions/sess_1rk8hhcn14q17n3on3jbg4m8uq