Light-mediated multi-target protein degradation using arylazopyrazole photoswitchable PROTACs (AP-PROTACs)

Light-activable spatiotemporal control of PROTAC-induced protein degradation was achieved with novel arylazopyrazole photoswitchable PROTACs (AP-PROTACs). The use of a promiscuous kinase inhibitor in the design enables this unique photoswitchable PROTAC to selectively degrade four protein kinases to...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Qisi, Kounde, Cyrille S., Mondal, Milon, Greenfield, Jake L., Baker, Jennifer R., Kotelnikov, Sergei, Ignatov, Mikhail, Tinworth, Christopher P., Zhang, Leran, Conole, Daniel, De Vita, Elena, Kozakov, Dima, McCluskey, Adam, Harling, John D., Fuchter, Matthew J., Tate, Edward W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9521323/
https://www.ncbi.nlm.nih.gov/pubmed/36065962
http://dx.doi.org/10.1039/d2cc03092f
Descripción
Sumario:Light-activable spatiotemporal control of PROTAC-induced protein degradation was achieved with novel arylazopyrazole photoswitchable PROTACs (AP-PROTACs). The use of a promiscuous kinase inhibitor in the design enables this unique photoswitchable PROTAC to selectively degrade four protein kinases together with on/off optical control using different wavelengths of light.

Ejemplares similares