Light-mediated multi-target protein degradation using arylazopyrazole photoswitchable PROTACs (AP-PROTACs)

Light-activable spatiotemporal control of PROTAC-induced protein degradation was achieved with novel arylazopyrazole photoswitchable PROTACs (AP-PROTACs). The use of a promiscuous kinase inhibitor in the design enables this unique photoswitchable PROTAC to selectively degrade four protein kinases to...

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Detalles Bibliográficos
Autores principales: Zhang, Qisi, Kounde, Cyrille S., Mondal, Milon, Greenfield, Jake L., Baker, Jennifer R., Kotelnikov, Sergei, Ignatov, Mikhail, Tinworth, Christopher P., Zhang, Leran, Conole, Daniel, De Vita, Elena, Kozakov, Dima, McCluskey, Adam, Harling, John D., Fuchter, Matthew J., Tate, Edward W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9521323/
https://www.ncbi.nlm.nih.gov/pubmed/36065962
http://dx.doi.org/10.1039/d2cc03092f
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author Zhang, Qisi
Kounde, Cyrille S.
Mondal, Milon
Greenfield, Jake L.
Baker, Jennifer R.
Kotelnikov, Sergei
Ignatov, Mikhail
Tinworth, Christopher P.
Zhang, Leran
Conole, Daniel
De Vita, Elena
Kozakov, Dima
McCluskey, Adam
Harling, John D.
Fuchter, Matthew J.
Tate, Edward W.
author_facet Zhang, Qisi
Kounde, Cyrille S.
Mondal, Milon
Greenfield, Jake L.
Baker, Jennifer R.
Kotelnikov, Sergei
Ignatov, Mikhail
Tinworth, Christopher P.
Zhang, Leran
Conole, Daniel
De Vita, Elena
Kozakov, Dima
McCluskey, Adam
Harling, John D.
Fuchter, Matthew J.
Tate, Edward W.
author_sort Zhang, Qisi
collection PubMed
description Light-activable spatiotemporal control of PROTAC-induced protein degradation was achieved with novel arylazopyrazole photoswitchable PROTACs (AP-PROTACs). The use of a promiscuous kinase inhibitor in the design enables this unique photoswitchable PROTAC to selectively degrade four protein kinases together with on/off optical control using different wavelengths of light.
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spelling pubmed-95213232022-10-31 Light-mediated multi-target protein degradation using arylazopyrazole photoswitchable PROTACs (AP-PROTACs) Zhang, Qisi Kounde, Cyrille S. Mondal, Milon Greenfield, Jake L. Baker, Jennifer R. Kotelnikov, Sergei Ignatov, Mikhail Tinworth, Christopher P. Zhang, Leran Conole, Daniel De Vita, Elena Kozakov, Dima McCluskey, Adam Harling, John D. Fuchter, Matthew J. Tate, Edward W. Chem Commun (Camb) Chemistry Light-activable spatiotemporal control of PROTAC-induced protein degradation was achieved with novel arylazopyrazole photoswitchable PROTACs (AP-PROTACs). The use of a promiscuous kinase inhibitor in the design enables this unique photoswitchable PROTAC to selectively degrade four protein kinases together with on/off optical control using different wavelengths of light. The Royal Society of Chemistry 2022-09-01 /pmc/articles/PMC9521323/ /pubmed/36065962 http://dx.doi.org/10.1039/d2cc03092f Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Zhang, Qisi
Kounde, Cyrille S.
Mondal, Milon
Greenfield, Jake L.
Baker, Jennifer R.
Kotelnikov, Sergei
Ignatov, Mikhail
Tinworth, Christopher P.
Zhang, Leran
Conole, Daniel
De Vita, Elena
Kozakov, Dima
McCluskey, Adam
Harling, John D.
Fuchter, Matthew J.
Tate, Edward W.
Light-mediated multi-target protein degradation using arylazopyrazole photoswitchable PROTACs (AP-PROTACs)
title Light-mediated multi-target protein degradation using arylazopyrazole photoswitchable PROTACs (AP-PROTACs)
title_full Light-mediated multi-target protein degradation using arylazopyrazole photoswitchable PROTACs (AP-PROTACs)
title_fullStr Light-mediated multi-target protein degradation using arylazopyrazole photoswitchable PROTACs (AP-PROTACs)
title_full_unstemmed Light-mediated multi-target protein degradation using arylazopyrazole photoswitchable PROTACs (AP-PROTACs)
title_short Light-mediated multi-target protein degradation using arylazopyrazole photoswitchable PROTACs (AP-PROTACs)
title_sort light-mediated multi-target protein degradation using arylazopyrazole photoswitchable protacs (ap-protacs)
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9521323/
https://www.ncbi.nlm.nih.gov/pubmed/36065962
http://dx.doi.org/10.1039/d2cc03092f
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