Light-mediated multi-target protein degradation using arylazopyrazole photoswitchable PROTACs (AP-PROTACs)

Light-activable spatiotemporal control of PROTAC-induced protein degradation was achieved with novel arylazopyrazole photoswitchable PROTACs (AP-PROTACs). The use of a promiscuous kinase inhibitor in the design enables this unique photoswitchable PROTAC to selectively degrade four protein kinases to...

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Detalles Bibliográficos
Autores principales: Zhang, Qisi, Kounde, Cyrille S., Mondal, Milon, Greenfield, Jake L., Baker, Jennifer R., Kotelnikov, Sergei, Ignatov, Mikhail, Tinworth, Christopher P., Zhang, Leran, Conole, Daniel, De Vita, Elena, Kozakov, Dima, McCluskey, Adam, Harling, John D., Fuchter, Matthew J., Tate, Edward W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9521323/
https://www.ncbi.nlm.nih.gov/pubmed/36065962
http://dx.doi.org/10.1039/d2cc03092f

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9521323/
https://www.ncbi.nlm.nih.gov/pubmed/36065962
http://dx.doi.org/10.1039/d2cc03092f

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