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Light-mediated multi-target protein degradation using arylazopyrazole photoswitchable PROTACs (AP-PROTACs)
Light-activable spatiotemporal control of PROTAC-induced protein degradation was achieved with novel arylazopyrazole photoswitchable PROTACs (AP-PROTACs). The use of a promiscuous kinase inhibitor in the design enables this unique photoswitchable PROTAC to selectively degrade four protein kinases to...
Autores principales: | Zhang, Qisi, Kounde, Cyrille S., Mondal, Milon, Greenfield, Jake L., Baker, Jennifer R., Kotelnikov, Sergei, Ignatov, Mikhail, Tinworth, Christopher P., Zhang, Leran, Conole, Daniel, De Vita, Elena, Kozakov, Dima, McCluskey, Adam, Harling, John D., Fuchter, Matthew J., Tate, Edward W. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9521323/ https://www.ncbi.nlm.nih.gov/pubmed/36065962 http://dx.doi.org/10.1039/d2cc03092f |
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