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Distribution, trends, and antifungal susceptibility of Candida species causing candidemia in Japan, 2010–2019: A retrospective observational study based on national surveillance data
The increasing incidence of candidemia and the emergence of drug-resistant Candida species are major concerns worldwide. Therefore, long-term surveillance studies are required. Here, we provide one of the largest longitudinal overviews of the trends in the prevalence of Candida species using nationa...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9521341/ https://www.ncbi.nlm.nih.gov/pubmed/36095139 http://dx.doi.org/10.1093/mmy/myac071 |
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author | Kajihara, Toshiki Yahara, Koji Nagi, Minoru Kitamura, Norikazu Hirabayashi, Aki Hosaka, Yumiko Abe, Masahiro Miyazaki, Yoshitsugu Sugai, Motoyuki |
author_facet | Kajihara, Toshiki Yahara, Koji Nagi, Minoru Kitamura, Norikazu Hirabayashi, Aki Hosaka, Yumiko Abe, Masahiro Miyazaki, Yoshitsugu Sugai, Motoyuki |
author_sort | Kajihara, Toshiki |
collection | PubMed |
description | The increasing incidence of candidemia and the emergence of drug-resistant Candida species are major concerns worldwide. Therefore, long-term surveillance studies are required. Here, we provide one of the largest longitudinal overviews of the trends in the prevalence of Candida species using national data of 57 001 candidemia isolates obtained from > 2000 hospitals for the 2010–2019 period in the Japan Nosocomial Infections Surveillance database. The proportion of Candida species, except Candida krusei and Candida guilliermondii, was almost the same during the study period. The proportion of C. guilliermondii surpassed that of C. krusei in 2014. The incidence of candidemia due to C. albicans (P < 0.0001), C. parapsilosis (P = 0.0002), and C. tropicalis (P < 0.0001) have decreased significantly over this period. Azole susceptibility of C. tropicalis was low, with 17.8% of isolates resistant to fluconazole and 13.5% resistant to voriconazole. The micafungin susceptibility of C. glabrata was low, with 8.0% of isolates showing resistance. The resistance rate of C. krusei toward amphotericin B fluctuated considerably (between 3.2% and 35.7%) over this period. The incidence rate of candidemia caused by C. parapsilosis and C. guilliermondii in hospitals responsible for bone marrow transplantation was significantly higher than that in other hospitals. Overall, our study suggests that in Japan, the species distribution of Candida was almost the same in this period and similar to that reported in North America and Europe. A relatively high resistance to azoles and micafungin was observed in C. glabrata, C. tropicalis, and C. krusei isolates, which require continued surveillance. |
format | Online Article Text |
id | pubmed-9521341 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-95213412022-10-03 Distribution, trends, and antifungal susceptibility of Candida species causing candidemia in Japan, 2010–2019: A retrospective observational study based on national surveillance data Kajihara, Toshiki Yahara, Koji Nagi, Minoru Kitamura, Norikazu Hirabayashi, Aki Hosaka, Yumiko Abe, Masahiro Miyazaki, Yoshitsugu Sugai, Motoyuki Med Mycol Original Article The increasing incidence of candidemia and the emergence of drug-resistant Candida species are major concerns worldwide. Therefore, long-term surveillance studies are required. Here, we provide one of the largest longitudinal overviews of the trends in the prevalence of Candida species using national data of 57 001 candidemia isolates obtained from > 2000 hospitals for the 2010–2019 period in the Japan Nosocomial Infections Surveillance database. The proportion of Candida species, except Candida krusei and Candida guilliermondii, was almost the same during the study period. The proportion of C. guilliermondii surpassed that of C. krusei in 2014. The incidence of candidemia due to C. albicans (P < 0.0001), C. parapsilosis (P = 0.0002), and C. tropicalis (P < 0.0001) have decreased significantly over this period. Azole susceptibility of C. tropicalis was low, with 17.8% of isolates resistant to fluconazole and 13.5% resistant to voriconazole. The micafungin susceptibility of C. glabrata was low, with 8.0% of isolates showing resistance. The resistance rate of C. krusei toward amphotericin B fluctuated considerably (between 3.2% and 35.7%) over this period. The incidence rate of candidemia caused by C. parapsilosis and C. guilliermondii in hospitals responsible for bone marrow transplantation was significantly higher than that in other hospitals. Overall, our study suggests that in Japan, the species distribution of Candida was almost the same in this period and similar to that reported in North America and Europe. A relatively high resistance to azoles and micafungin was observed in C. glabrata, C. tropicalis, and C. krusei isolates, which require continued surveillance. Oxford University Press 2022-09-12 /pmc/articles/PMC9521341/ /pubmed/36095139 http://dx.doi.org/10.1093/mmy/myac071 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of The International Society for Human and Animal Mycology. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Kajihara, Toshiki Yahara, Koji Nagi, Minoru Kitamura, Norikazu Hirabayashi, Aki Hosaka, Yumiko Abe, Masahiro Miyazaki, Yoshitsugu Sugai, Motoyuki Distribution, trends, and antifungal susceptibility of Candida species causing candidemia in Japan, 2010–2019: A retrospective observational study based on national surveillance data |
title | Distribution, trends, and antifungal susceptibility of Candida species causing candidemia in Japan, 2010–2019: A retrospective observational study based on national surveillance data |
title_full | Distribution, trends, and antifungal susceptibility of Candida species causing candidemia in Japan, 2010–2019: A retrospective observational study based on national surveillance data |
title_fullStr | Distribution, trends, and antifungal susceptibility of Candida species causing candidemia in Japan, 2010–2019: A retrospective observational study based on national surveillance data |
title_full_unstemmed | Distribution, trends, and antifungal susceptibility of Candida species causing candidemia in Japan, 2010–2019: A retrospective observational study based on national surveillance data |
title_short | Distribution, trends, and antifungal susceptibility of Candida species causing candidemia in Japan, 2010–2019: A retrospective observational study based on national surveillance data |
title_sort | distribution, trends, and antifungal susceptibility of candida species causing candidemia in japan, 2010–2019: a retrospective observational study based on national surveillance data |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9521341/ https://www.ncbi.nlm.nih.gov/pubmed/36095139 http://dx.doi.org/10.1093/mmy/myac071 |
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