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Different oral and gut microbial profiles in those with Alzheimer's disease consuming anti-inflammatory diets

The number of people living with Alzheimer's disease (AD) is increasing alongside with aging of the population. Systemic chronic inflammation and microbial imbalance may play an important role in the pathogenesis of AD. Inflammatory diets regulate both the host microbiomes and inflammatory stat...

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Autores principales: Chen, Lili, Wang, Bixia, Liu, Jinxiu, Wu, Xiaoqi, Xu, Xinhua, Cao, Huizhen, Ji, Xinli, Zhang, Ping, Li, Xiuli, Hou, Zhaoyi, Li, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9521405/
https://www.ncbi.nlm.nih.gov/pubmed/36185672
http://dx.doi.org/10.3389/fnut.2022.974694
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author Chen, Lili
Wang, Bixia
Liu, Jinxiu
Wu, Xiaoqi
Xu, Xinhua
Cao, Huizhen
Ji, Xinli
Zhang, Ping
Li, Xiuli
Hou, Zhaoyi
Li, Hong
author_facet Chen, Lili
Wang, Bixia
Liu, Jinxiu
Wu, Xiaoqi
Xu, Xinhua
Cao, Huizhen
Ji, Xinli
Zhang, Ping
Li, Xiuli
Hou, Zhaoyi
Li, Hong
author_sort Chen, Lili
collection PubMed
description The number of people living with Alzheimer's disease (AD) is increasing alongside with aging of the population. Systemic chronic inflammation and microbial imbalance may play an important role in the pathogenesis of AD. Inflammatory diets regulate both the host microbiomes and inflammatory status. This study aimed to explore the impact of inflammatory diets on oral-gut microbes in patients with AD and the relationship between microbes and markers of systemic inflammation. The dietary inflammatory properties and the oral and gut microorganisms were analyzed using the dietary inflammatory index (DII) and 16S RNA in 60 patients with AD. The α-diversity was not related to the DII (p > 0.05), whereas the β-diversity was different in the oral microbiomes (R(2) = 0.061, p = 0.013). In the most anti-inflammatory diet group, Prevotella and Olsenella were more abundant in oral microbiomes and Alistipes, Ruminococcus, Odoribacter, and unclassified Firmicutes were in the gut microbiomes (p < 0.05). Specific oral and gut genera were associated with interleukin-6 (IL)-6, complement 3 (C3), high-sensitivity C-reactive protein (hs-CRP), IL-1β, IL-4, IL-10, IL-12, and tumor necrosis factor-α (TNF-α) (p < 0.05). In conclusion, anti-inflammatory diets seem to be associated with increased abundance of beneficial microbes, and specific oral and gut microbial composition was associated with inflammatory markers.
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spelling pubmed-95214052022-09-30 Different oral and gut microbial profiles in those with Alzheimer's disease consuming anti-inflammatory diets Chen, Lili Wang, Bixia Liu, Jinxiu Wu, Xiaoqi Xu, Xinhua Cao, Huizhen Ji, Xinli Zhang, Ping Li, Xiuli Hou, Zhaoyi Li, Hong Front Nutr Nutrition The number of people living with Alzheimer's disease (AD) is increasing alongside with aging of the population. Systemic chronic inflammation and microbial imbalance may play an important role in the pathogenesis of AD. Inflammatory diets regulate both the host microbiomes and inflammatory status. This study aimed to explore the impact of inflammatory diets on oral-gut microbes in patients with AD and the relationship between microbes and markers of systemic inflammation. The dietary inflammatory properties and the oral and gut microorganisms were analyzed using the dietary inflammatory index (DII) and 16S RNA in 60 patients with AD. The α-diversity was not related to the DII (p > 0.05), whereas the β-diversity was different in the oral microbiomes (R(2) = 0.061, p = 0.013). In the most anti-inflammatory diet group, Prevotella and Olsenella were more abundant in oral microbiomes and Alistipes, Ruminococcus, Odoribacter, and unclassified Firmicutes were in the gut microbiomes (p < 0.05). Specific oral and gut genera were associated with interleukin-6 (IL)-6, complement 3 (C3), high-sensitivity C-reactive protein (hs-CRP), IL-1β, IL-4, IL-10, IL-12, and tumor necrosis factor-α (TNF-α) (p < 0.05). In conclusion, anti-inflammatory diets seem to be associated with increased abundance of beneficial microbes, and specific oral and gut microbial composition was associated with inflammatory markers. Frontiers Media S.A. 2022-09-15 /pmc/articles/PMC9521405/ /pubmed/36185672 http://dx.doi.org/10.3389/fnut.2022.974694 Text en Copyright © 2022 Chen, Wang, Liu, Wu, Xu, Cao, Ji, Zhang, Li, Hou and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Chen, Lili
Wang, Bixia
Liu, Jinxiu
Wu, Xiaoqi
Xu, Xinhua
Cao, Huizhen
Ji, Xinli
Zhang, Ping
Li, Xiuli
Hou, Zhaoyi
Li, Hong
Different oral and gut microbial profiles in those with Alzheimer's disease consuming anti-inflammatory diets
title Different oral and gut microbial profiles in those with Alzheimer's disease consuming anti-inflammatory diets
title_full Different oral and gut microbial profiles in those with Alzheimer's disease consuming anti-inflammatory diets
title_fullStr Different oral and gut microbial profiles in those with Alzheimer's disease consuming anti-inflammatory diets
title_full_unstemmed Different oral and gut microbial profiles in those with Alzheimer's disease consuming anti-inflammatory diets
title_short Different oral and gut microbial profiles in those with Alzheimer's disease consuming anti-inflammatory diets
title_sort different oral and gut microbial profiles in those with alzheimer's disease consuming anti-inflammatory diets
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9521405/
https://www.ncbi.nlm.nih.gov/pubmed/36185672
http://dx.doi.org/10.3389/fnut.2022.974694
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