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Brain fingerprints along the language hierarchy

Recent studies have shown that the brain functional connectome constitutes a unique fingerprint that allows the identification of individuals from a group. However, what information encoded in the brain that makes us unique remains elusive. Here, we addressed this issue by examining how individual i...

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Autores principales: Zhang, Juan, Zhuang, Liping, Jiang, Jiahao, Yang, Menghan, Li, Shijie, Tang, Xiangrong, Ma, Yingbo, Liu, Lanfang, Ding, Guosheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9521489/
https://www.ncbi.nlm.nih.gov/pubmed/36188171
http://dx.doi.org/10.3389/fnhum.2022.982905
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author Zhang, Juan
Zhuang, Liping
Jiang, Jiahao
Yang, Menghan
Li, Shijie
Tang, Xiangrong
Ma, Yingbo
Liu, Lanfang
Ding, Guosheng
author_facet Zhang, Juan
Zhuang, Liping
Jiang, Jiahao
Yang, Menghan
Li, Shijie
Tang, Xiangrong
Ma, Yingbo
Liu, Lanfang
Ding, Guosheng
author_sort Zhang, Juan
collection PubMed
description Recent studies have shown that the brain functional connectome constitutes a unique fingerprint that allows the identification of individuals from a group. However, what information encoded in the brain that makes us unique remains elusive. Here, we addressed this issue by examining how individual identifiability changed along the language hierarchy. Subjects underwent fMRI scanning during rest and when listening to short stories played backward, scrambled at the sentence level, and played forward. Identification for individuals was performed between two scan sessions for each task as well as between the rest and task sessions. We found that individual identifiability tends to increase along the language hierarchy: the more complex the task is, the better subjects can be distinguished from each other based on their whole-brain functional connectivity profiles. A similar principle is found at the functional network level: compared to the low-order network (the auditory network), the high-order network is more individualized (the frontoparietal network). Moreover, in both cases, the increase in individual identifiability is accompanied by the increase in inter-subject variability of functional connectivities. These findings advance the understanding of the source of brain individualization and have potential implications for developing robust connectivity-based biomarkers.
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spelling pubmed-95214892022-09-30 Brain fingerprints along the language hierarchy Zhang, Juan Zhuang, Liping Jiang, Jiahao Yang, Menghan Li, Shijie Tang, Xiangrong Ma, Yingbo Liu, Lanfang Ding, Guosheng Front Hum Neurosci Human Neuroscience Recent studies have shown that the brain functional connectome constitutes a unique fingerprint that allows the identification of individuals from a group. However, what information encoded in the brain that makes us unique remains elusive. Here, we addressed this issue by examining how individual identifiability changed along the language hierarchy. Subjects underwent fMRI scanning during rest and when listening to short stories played backward, scrambled at the sentence level, and played forward. Identification for individuals was performed between two scan sessions for each task as well as between the rest and task sessions. We found that individual identifiability tends to increase along the language hierarchy: the more complex the task is, the better subjects can be distinguished from each other based on their whole-brain functional connectivity profiles. A similar principle is found at the functional network level: compared to the low-order network (the auditory network), the high-order network is more individualized (the frontoparietal network). Moreover, in both cases, the increase in individual identifiability is accompanied by the increase in inter-subject variability of functional connectivities. These findings advance the understanding of the source of brain individualization and have potential implications for developing robust connectivity-based biomarkers. Frontiers Media S.A. 2022-09-15 /pmc/articles/PMC9521489/ /pubmed/36188171 http://dx.doi.org/10.3389/fnhum.2022.982905 Text en Copyright © 2022 Zhang, Zhuang, Jiang, Yang, Li, Tang, Ma, Liu and Ding. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Human Neuroscience
Zhang, Juan
Zhuang, Liping
Jiang, Jiahao
Yang, Menghan
Li, Shijie
Tang, Xiangrong
Ma, Yingbo
Liu, Lanfang
Ding, Guosheng
Brain fingerprints along the language hierarchy
title Brain fingerprints along the language hierarchy
title_full Brain fingerprints along the language hierarchy
title_fullStr Brain fingerprints along the language hierarchy
title_full_unstemmed Brain fingerprints along the language hierarchy
title_short Brain fingerprints along the language hierarchy
title_sort brain fingerprints along the language hierarchy
topic Human Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9521489/
https://www.ncbi.nlm.nih.gov/pubmed/36188171
http://dx.doi.org/10.3389/fnhum.2022.982905
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