SARS-CoV-2 infects adipose tissue in a fat depot- and viral lineage-dependent manner

Visceral adiposity is a risk factor for severe COVID-19, and a link between adipose tissue infection and disease progression has been proposed. Here we demonstrate that SARS-CoV-2 infects human adipose tissue and undergoes productive infection in fat cells. However, susceptibility to infection and t...

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Autores principales: Saccon, Tatiana Dandolini, Mousovich-Neto, Felippe, Ludwig, Raissa Guimarães, Carregari, Victor Corasolla, dos Anjos Souza, Ana Beatriz, dos Passos, Amanda Stephane Cruz, Martini, Matheus Cavalheiro, Barbosa, Priscilla Paschoal, de Souza, Gabriela Fabiano, Muraro, Stéfanie Primon, Forato, Julia, Amorim, Mariene Ribeiro, Marques, Rafael Elias, Veras, Flavio Protasio, Barreto, Ester, Gonçalves, Tiago Tomazini, Paiva, Isadora Marques, Fazolini, Narayana P. B., Onodera, Carolina Mie Kawagosi, Martins Junior, Ronaldo Bragança, de Araújo, Paulo Henrique Cavalcanti, Batah, Sabrina Setembre, Viana, Rosa Maria Mendes, de Melo, Danilo Machado, Fabro, Alexandre Todorovic, Arruda, Eurico, Queiroz Cunha, Fernando, Cunha, Thiago Mattar, Pretti, Marco Antônio M., Smith, Bradley Joseph, Marques-Souza, Henrique, Knittel, Thiago L., Ruiz, Gabriel Palermo, Profeta, Gerson S., Fontes-Cal, Tereza Cristina Minto, Boroni, Mariana, Vinolo, Marco Aurélio Ramirez, Farias, Alessandro S., Moraes-Vieira, Pedro Manoel M., Bizzacchi, Joyce Maria Annichino, Teesalu, Tambet, Chaim, Felipe David Mendonça, Cazzo, Everton, Chaim, Elinton Adami, Proença-Módena, José Luiz, Martins-de-Souza, Daniel, Osako, Mariana Kiomy, Leiria, Luiz Osório, Mori, Marcelo A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9521555/
https://www.ncbi.nlm.nih.gov/pubmed/36175400
http://dx.doi.org/10.1038/s41467-022-33218-8

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