Cardiac Arrest Following Remimazolam-Induced Anaphylaxis: A Case Report

Remimazolam is a recently approved benzodiazepine sedative. We report a case of a 72-year-old man who experienced a cardiac arrest due to severe anaphylaxis immediately after general anesthesia induction. Based on the results of skin tests, including those for dextran 40, an excipient in the remimaz...

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Detalles Bibliográficos
Autores principales: Hasushita, Yudai, Nagao, Megumi, Miyazawa, Yoshihide, Yunoki, Kazuma, Mima, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Cardiovascular Anesthesiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9521581/
https://www.ncbi.nlm.nih.gov/pubmed/36149988
http://dx.doi.org/10.1213/XAA.0000000000001616
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author Hasushita, Yudai
Nagao, Megumi
Miyazawa, Yoshihide
Yunoki, Kazuma
Mima, Hiroyuki
author_facet Hasushita, Yudai
Nagao, Megumi
Miyazawa, Yoshihide
Yunoki, Kazuma
Mima, Hiroyuki
author_sort Hasushita, Yudai
collection PubMed
description Remimazolam is a recently approved benzodiazepine sedative. We report a case of a 72-year-old man who experienced a cardiac arrest due to severe anaphylaxis immediately after general anesthesia induction. Based on the results of skin tests, including those for dextran 40, an excipient in the remimazolam solution, and a review of drugs given during 3 anesthetics, remimazolam was identified as the probable causative agent. Although remimazolam is structurally similar to midazolam, the patient was not allergic to midazolam as demonstrated before and after anaphylaxis. This report highlights the potential risk of allergic reactions to remimazolam.
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spelling pubmed-95215812022-10-03 Cardiac Arrest Following Remimazolam-Induced Anaphylaxis: A Case Report Hasushita, Yudai Nagao, Megumi Miyazawa, Yoshihide Yunoki, Kazuma Mima, Hiroyuki A A Pract Cardiovascular Anesthesiology Remimazolam is a recently approved benzodiazepine sedative. We report a case of a 72-year-old man who experienced a cardiac arrest due to severe anaphylaxis immediately after general anesthesia induction. Based on the results of skin tests, including those for dextran 40, an excipient in the remimazolam solution, and a review of drugs given during 3 anesthetics, remimazolam was identified as the probable causative agent. Although remimazolam is structurally similar to midazolam, the patient was not allergic to midazolam as demonstrated before and after anaphylaxis. This report highlights the potential risk of allergic reactions to remimazolam. Lippincott Williams & Wilkins 2022-09-23 /pmc/articles/PMC9521581/ /pubmed/36149988 http://dx.doi.org/10.1213/XAA.0000000000001616 Text en Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the International Anesthesia Research Society. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Cardiovascular Anesthesiology
Hasushita, Yudai
Nagao, Megumi
Miyazawa, Yoshihide
Yunoki, Kazuma
Mima, Hiroyuki
Cardiac Arrest Following Remimazolam-Induced Anaphylaxis: A Case Report
title Cardiac Arrest Following Remimazolam-Induced Anaphylaxis: A Case Report
title_full Cardiac Arrest Following Remimazolam-Induced Anaphylaxis: A Case Report
title_fullStr Cardiac Arrest Following Remimazolam-Induced Anaphylaxis: A Case Report
title_full_unstemmed Cardiac Arrest Following Remimazolam-Induced Anaphylaxis: A Case Report
title_short Cardiac Arrest Following Remimazolam-Induced Anaphylaxis: A Case Report
title_sort cardiac arrest following remimazolam-induced anaphylaxis: a case report
topic Cardiovascular Anesthesiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9521581/
https://www.ncbi.nlm.nih.gov/pubmed/36149988
http://dx.doi.org/10.1213/XAA.0000000000001616
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