Development of microparticles for oral administration of Periplaneta americana extract to treat ulcerative colitis

Ulcerative colitis (UC) is a chronic disease, which can result the inflammation of the rectum, mucosa of the colon, and submucosa. The active component such as polypeptide in Periplaneta americana, which is one of the most common insects in the nature, can be extracted to treat UC. However, the acti...

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Detalles Bibliográficos
Autores principales: Li, Meng, Wu, Hao, Wang, Shuang, Wu, Shengshun, Han, Jing, Han, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9521608/
https://www.ncbi.nlm.nih.gov/pubmed/35982644
http://dx.doi.org/10.1080/10717544.2022.2112115
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author Li, Meng
Wu, Hao
Wang, Shuang
Wu, Shengshun
Han, Jing
Han, Yang
author_facet Li, Meng
Wu, Hao
Wang, Shuang
Wu, Shengshun
Han, Jing
Han, Yang
author_sort Li, Meng
collection PubMed
description Ulcerative colitis (UC) is a chronic disease, which can result the inflammation of the rectum, mucosa of the colon, and submucosa. The active component such as polypeptide in Periplaneta americana, which is one of the most common insects in the nature, can be extracted to treat UC. However, the active components in Periplaneta americana extract (PAE) can be degraded in the stomach due to its extreme acidic environment and enzyme. In this study, we developed a pH-dependent drug delivery method using polymer cellulose acetate (Eudragit S100) as a carrier to deliver high concentration PAE to inflamed colon. Both in vitro and in vivo results showed the PAE-Eudragit-S100 could treat UC through delivering active drug components to colon without degradation.
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spelling pubmed-95216082022-09-30 Development of microparticles for oral administration of Periplaneta americana extract to treat ulcerative colitis Li, Meng Wu, Hao Wang, Shuang Wu, Shengshun Han, Jing Han, Yang Drug Deliv Research Article Ulcerative colitis (UC) is a chronic disease, which can result the inflammation of the rectum, mucosa of the colon, and submucosa. The active component such as polypeptide in Periplaneta americana, which is one of the most common insects in the nature, can be extracted to treat UC. However, the active components in Periplaneta americana extract (PAE) can be degraded in the stomach due to its extreme acidic environment and enzyme. In this study, we developed a pH-dependent drug delivery method using polymer cellulose acetate (Eudragit S100) as a carrier to deliver high concentration PAE to inflamed colon. Both in vitro and in vivo results showed the PAE-Eudragit-S100 could treat UC through delivering active drug components to colon without degradation. Taylor & Francis 2022-08-18 /pmc/articles/PMC9521608/ /pubmed/35982644 http://dx.doi.org/10.1080/10717544.2022.2112115 Text en © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Li, Meng
Wu, Hao
Wang, Shuang
Wu, Shengshun
Han, Jing
Han, Yang
Development of microparticles for oral administration of Periplaneta americana extract to treat ulcerative colitis
title Development of microparticles for oral administration of Periplaneta americana extract to treat ulcerative colitis
title_full Development of microparticles for oral administration of Periplaneta americana extract to treat ulcerative colitis
title_fullStr Development of microparticles for oral administration of Periplaneta americana extract to treat ulcerative colitis
title_full_unstemmed Development of microparticles for oral administration of Periplaneta americana extract to treat ulcerative colitis
title_short Development of microparticles for oral administration of Periplaneta americana extract to treat ulcerative colitis
title_sort development of microparticles for oral administration of periplaneta americana extract to treat ulcerative colitis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9521608/
https://www.ncbi.nlm.nih.gov/pubmed/35982644
http://dx.doi.org/10.1080/10717544.2022.2112115
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