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Expression and clinical significance of CD31, CD34, and CD105 in pulmonary ground glass nodules with different vascular manifestations on CT

Blood vessel passage on CT exerts a vital part in early diagnosis as well as treatment of carcinoma of the lungs. Intratumoral microvascular density (iMVD) has gradually become the focus of research on biological behavior, appearance, and evolution of malignant tumors nowadays. The aim of this paper...

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Autores principales: Guo, Chen-ran, Han, Rui, Xue, Feng, Xu, Lin, Ren, Wan-gang, Li, Meng, Feng, Zhen, Hu, Ben-chuang, Peng, Zhong-min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9521677/
https://www.ncbi.nlm.nih.gov/pubmed/36185269
http://dx.doi.org/10.3389/fonc.2022.956451
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author Guo, Chen-ran
Han, Rui
Xue, Feng
Xu, Lin
Ren, Wan-gang
Li, Meng
Feng, Zhen
Hu, Ben-chuang
Peng, Zhong-min
author_facet Guo, Chen-ran
Han, Rui
Xue, Feng
Xu, Lin
Ren, Wan-gang
Li, Meng
Feng, Zhen
Hu, Ben-chuang
Peng, Zhong-min
author_sort Guo, Chen-ran
collection PubMed
description Blood vessel passage on CT exerts a vital part in early diagnosis as well as treatment of carcinoma of the lungs. Intratumoral microvascular density (iMVD) has gradually become the focus of research on biological behavior, appearance, and evolution of malignant tumors nowadays. The aim of this paper was to verify whether there is a correlation between the iMVD and the vascular morphology of ground glass nodules (GGNs). A total of 109 patients with pulmonary GGN were classified into three groups (I,II, and III) according to the vascular morphology on CT, and their expression of CD31-, CD34-, and CD105-labeled iMVD was detected by the streptoavidin–biotin method, statistically analyzing the iMVD values of each group. The expression of CD31, CD34, and CD105 in different lung tissues was significantly different, with remarkably higher iMVD in lung cancer tissues than in adjacent normal lung tissues. In the imaging sort of types I, II, and III according to the means of vascular passage, the iMVD expression of CD31, CD34, and CD105 was significantly different between groups. These data suggest that the presence and the abnormal morphology of vessels seen within GGNs indicate the occurrence and progression of lung cancer in pathology. It offers a strong theoretical foundation for early diagnosis of carcinoma of the lungs, thus providing a more precise clinical diagnosis and prognosis of early-stage lung cancer.
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spelling pubmed-95216772022-09-30 Expression and clinical significance of CD31, CD34, and CD105 in pulmonary ground glass nodules with different vascular manifestations on CT Guo, Chen-ran Han, Rui Xue, Feng Xu, Lin Ren, Wan-gang Li, Meng Feng, Zhen Hu, Ben-chuang Peng, Zhong-min Front Oncol Oncology Blood vessel passage on CT exerts a vital part in early diagnosis as well as treatment of carcinoma of the lungs. Intratumoral microvascular density (iMVD) has gradually become the focus of research on biological behavior, appearance, and evolution of malignant tumors nowadays. The aim of this paper was to verify whether there is a correlation between the iMVD and the vascular morphology of ground glass nodules (GGNs). A total of 109 patients with pulmonary GGN were classified into three groups (I,II, and III) according to the vascular morphology on CT, and their expression of CD31-, CD34-, and CD105-labeled iMVD was detected by the streptoavidin–biotin method, statistically analyzing the iMVD values of each group. The expression of CD31, CD34, and CD105 in different lung tissues was significantly different, with remarkably higher iMVD in lung cancer tissues than in adjacent normal lung tissues. In the imaging sort of types I, II, and III according to the means of vascular passage, the iMVD expression of CD31, CD34, and CD105 was significantly different between groups. These data suggest that the presence and the abnormal morphology of vessels seen within GGNs indicate the occurrence and progression of lung cancer in pathology. It offers a strong theoretical foundation for early diagnosis of carcinoma of the lungs, thus providing a more precise clinical diagnosis and prognosis of early-stage lung cancer. Frontiers Media S.A. 2022-09-15 /pmc/articles/PMC9521677/ /pubmed/36185269 http://dx.doi.org/10.3389/fonc.2022.956451 Text en Copyright © 2022 Guo, Han, Xue, Xu, Ren, Li, Feng, Hu and Peng https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Guo, Chen-ran
Han, Rui
Xue, Feng
Xu, Lin
Ren, Wan-gang
Li, Meng
Feng, Zhen
Hu, Ben-chuang
Peng, Zhong-min
Expression and clinical significance of CD31, CD34, and CD105 in pulmonary ground glass nodules with different vascular manifestations on CT
title Expression and clinical significance of CD31, CD34, and CD105 in pulmonary ground glass nodules with different vascular manifestations on CT
title_full Expression and clinical significance of CD31, CD34, and CD105 in pulmonary ground glass nodules with different vascular manifestations on CT
title_fullStr Expression and clinical significance of CD31, CD34, and CD105 in pulmonary ground glass nodules with different vascular manifestations on CT
title_full_unstemmed Expression and clinical significance of CD31, CD34, and CD105 in pulmonary ground glass nodules with different vascular manifestations on CT
title_short Expression and clinical significance of CD31, CD34, and CD105 in pulmonary ground glass nodules with different vascular manifestations on CT
title_sort expression and clinical significance of cd31, cd34, and cd105 in pulmonary ground glass nodules with different vascular manifestations on ct
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9521677/
https://www.ncbi.nlm.nih.gov/pubmed/36185269
http://dx.doi.org/10.3389/fonc.2022.956451
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