A new personalized vaccine strategy based on inducing the pyroptosis of tumor cells in vivo by transgenic expression of a truncated GSDMD N-terminus

The variability and heterogeneity of tumor antigens and the tumor-driven development of immunosuppressive mechanisms leading to tumor escape from established immunological surveillance. Here, the tumor cells were genetically modified to achieve an inducible overexpression of the N-terminal domain of...

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Detalles Bibliográficos
Autores principales: He, Jinrong, Zheng, Peng, Chen, Yongjun, Qi, Jialong, Ye, Chao, Li, Duo, Yang, Ying, Liu, Qingwen, Hu, Yongmao, Zheng, Xiao, Li, Weiran, Hua, Liangqun, Yang, Zhongqian, Chen, Haoqian, Huang, Weiwei, Sun, Wenjia, Yang, Xu, Long, Qiong, Bai, Hongmei, Ma, Yanbing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9521720/
https://www.ncbi.nlm.nih.gov/pubmed/36189310
http://dx.doi.org/10.3389/fimmu.2022.991857

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