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Distinct mechanisms underlie H(2)O(2) sensing in C. elegans head and tail
Environmental oxidative stress threatens cellular integrity and should therefore be avoided by living organisms. Yet, relatively little is known about environmental oxidative stress perception. Here, using microfluidics, we showed that like I2 pharyngeal neurons, the tail phasmid PHA neurons functio...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9521893/ https://www.ncbi.nlm.nih.gov/pubmed/36173997 http://dx.doi.org/10.1371/journal.pone.0274226 |
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author | Quintin, Sophie Aspert, Théo Ye, Tao Charvin, Gilles |
author_facet | Quintin, Sophie Aspert, Théo Ye, Tao Charvin, Gilles |
author_sort | Quintin, Sophie |
collection | PubMed |
description | Environmental oxidative stress threatens cellular integrity and should therefore be avoided by living organisms. Yet, relatively little is known about environmental oxidative stress perception. Here, using microfluidics, we showed that like I2 pharyngeal neurons, the tail phasmid PHA neurons function as oxidative stress sensing neurons in C. elegans, but display different responses to H(2)O(2) and light. We uncovered that different but related receptors, GUR-3 and LITE-1, mediate H(2)O(2) signaling in I2 and PHA neurons. Still, the peroxiredoxin PRDX-2 is essential for both, and might promote H(2)O(2)-mediated receptor activation. Our work demonstrates that C. elegans can sense a broad range of oxidative stressors using partially distinct H(2)O(2) signaling pathways in head and tail sensillae, and paves the way for further understanding of how the integration of these inputs translates into the appropriate behavior. |
format | Online Article Text |
id | pubmed-9521893 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-95218932022-09-30 Distinct mechanisms underlie H(2)O(2) sensing in C. elegans head and tail Quintin, Sophie Aspert, Théo Ye, Tao Charvin, Gilles PLoS One Research Article Environmental oxidative stress threatens cellular integrity and should therefore be avoided by living organisms. Yet, relatively little is known about environmental oxidative stress perception. Here, using microfluidics, we showed that like I2 pharyngeal neurons, the tail phasmid PHA neurons function as oxidative stress sensing neurons in C. elegans, but display different responses to H(2)O(2) and light. We uncovered that different but related receptors, GUR-3 and LITE-1, mediate H(2)O(2) signaling in I2 and PHA neurons. Still, the peroxiredoxin PRDX-2 is essential for both, and might promote H(2)O(2)-mediated receptor activation. Our work demonstrates that C. elegans can sense a broad range of oxidative stressors using partially distinct H(2)O(2) signaling pathways in head and tail sensillae, and paves the way for further understanding of how the integration of these inputs translates into the appropriate behavior. Public Library of Science 2022-09-29 /pmc/articles/PMC9521893/ /pubmed/36173997 http://dx.doi.org/10.1371/journal.pone.0274226 Text en © 2022 Quintin et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Quintin, Sophie Aspert, Théo Ye, Tao Charvin, Gilles Distinct mechanisms underlie H(2)O(2) sensing in C. elegans head and tail |
title | Distinct mechanisms underlie H(2)O(2) sensing in C. elegans head and tail |
title_full | Distinct mechanisms underlie H(2)O(2) sensing in C. elegans head and tail |
title_fullStr | Distinct mechanisms underlie H(2)O(2) sensing in C. elegans head and tail |
title_full_unstemmed | Distinct mechanisms underlie H(2)O(2) sensing in C. elegans head and tail |
title_short | Distinct mechanisms underlie H(2)O(2) sensing in C. elegans head and tail |
title_sort | distinct mechanisms underlie h(2)o(2) sensing in c. elegans head and tail |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9521893/ https://www.ncbi.nlm.nih.gov/pubmed/36173997 http://dx.doi.org/10.1371/journal.pone.0274226 |
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