Thiopurines inhibit coronavirus Spike protein processing and incorporation into progeny virions

There is an outstanding need for broadly acting antiviral drugs to combat emerging viral diseases. Here, we report that thiopurines inhibit the replication of the betacoronaviruses HCoV-OC43 and SARS-CoV-2. 6-Thioguanine (6-TG) disrupted early stages of infection, limiting accumulation of full-lengt...

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Detalles Bibliográficos
Autores principales: Pringle, Eric S., Duguay, Brett A., Bui-Marinos, Maxwell P., Mulloy, Rory P., Landreth, Shelby L., Desireddy, Krishna Swaroop, Dolliver, Stacia M., Ying, Shan, Caddell, Taylor, Tooley, Trinity H., Slaine, Patrick D., Bearne, Stephen L., Falzarano, Darryl, Corcoran, Jennifer A., Khaperskyy, Denys A., McCormick, Craig
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9522307/
https://www.ncbi.nlm.nih.gov/pubmed/36121863
http://dx.doi.org/10.1371/journal.ppat.1010832

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9522307/
https://www.ncbi.nlm.nih.gov/pubmed/36121863
http://dx.doi.org/10.1371/journal.ppat.1010832

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