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Active neural coordination of motor behaviors with internal states

The brain continuously coordinates skeletomuscular movements with internal physiological states like arousal, but how is this coordination achieved? One possibility is that the brain simply reacts to changes in external and/or internal signals. Another possibility is that it is actively coordinating...

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Detalles Bibliográficos
Autores principales: Zhang, Yisi S., Takahashi, Daniel Y., El Hady, Ahmed, Liao, Diana A., Ghazanfar, Asif A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9522379/
https://www.ncbi.nlm.nih.gov/pubmed/36122243
http://dx.doi.org/10.1073/pnas.2201194119
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author Zhang, Yisi S.
Takahashi, Daniel Y.
El Hady, Ahmed
Liao, Diana A.
Ghazanfar, Asif A.
author_facet Zhang, Yisi S.
Takahashi, Daniel Y.
El Hady, Ahmed
Liao, Diana A.
Ghazanfar, Asif A.
author_sort Zhang, Yisi S.
collection PubMed
description The brain continuously coordinates skeletomuscular movements with internal physiological states like arousal, but how is this coordination achieved? One possibility is that the brain simply reacts to changes in external and/or internal signals. Another possibility is that it is actively coordinating both external and internal activities. We used functional ultrasound imaging to capture a large medial section of the brain, including multiple cortical and subcortical areas, in marmoset monkeys while monitoring their spontaneous movements and cardiac activity. By analyzing the causal ordering of these different time series, we found that information flowing from the brain to movements and heart-rate fluctuations were significantly greater than in the opposite direction. The brain areas involved in this external versus internal coordination were spatially distinct, but also extensively interconnected. Temporally, the brain alternated between network states for this regulation. These findings suggest that the brain’s dynamics actively and efficiently coordinate motor behavior with internal physiology.
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spelling pubmed-95223792023-03-19 Active neural coordination of motor behaviors with internal states Zhang, Yisi S. Takahashi, Daniel Y. El Hady, Ahmed Liao, Diana A. Ghazanfar, Asif A. Proc Natl Acad Sci U S A Biological Sciences The brain continuously coordinates skeletomuscular movements with internal physiological states like arousal, but how is this coordination achieved? One possibility is that the brain simply reacts to changes in external and/or internal signals. Another possibility is that it is actively coordinating both external and internal activities. We used functional ultrasound imaging to capture a large medial section of the brain, including multiple cortical and subcortical areas, in marmoset monkeys while monitoring their spontaneous movements and cardiac activity. By analyzing the causal ordering of these different time series, we found that information flowing from the brain to movements and heart-rate fluctuations were significantly greater than in the opposite direction. The brain areas involved in this external versus internal coordination were spatially distinct, but also extensively interconnected. Temporally, the brain alternated between network states for this regulation. These findings suggest that the brain’s dynamics actively and efficiently coordinate motor behavior with internal physiology. National Academy of Sciences 2022-09-19 2022-09-27 /pmc/articles/PMC9522379/ /pubmed/36122243 http://dx.doi.org/10.1073/pnas.2201194119 Text en Copyright © 2022 the Author(s). Published by PNAS. https://creativecommons.org/licenses/by-nc-nd/4.0/This article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Biological Sciences
Zhang, Yisi S.
Takahashi, Daniel Y.
El Hady, Ahmed
Liao, Diana A.
Ghazanfar, Asif A.
Active neural coordination of motor behaviors with internal states
title Active neural coordination of motor behaviors with internal states
title_full Active neural coordination of motor behaviors with internal states
title_fullStr Active neural coordination of motor behaviors with internal states
title_full_unstemmed Active neural coordination of motor behaviors with internal states
title_short Active neural coordination of motor behaviors with internal states
title_sort active neural coordination of motor behaviors with internal states
topic Biological Sciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9522379/
https://www.ncbi.nlm.nih.gov/pubmed/36122243
http://dx.doi.org/10.1073/pnas.2201194119
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