Oncogenic β-catenin stimulation of AKT2–CAD-mediated pyrimidine synthesis is targetable vulnerability in liver cancer

CTNNB1, encoding β-catenin protein, is the most frequently altered proto-oncogene in hepatic neoplasms. In this study, we studied the significance and pathological mechanism of CTNNB1 gain-of-function mutations in hepatocarcinogenesis. Activated β-catenin not only triggered hepatic tumorigenesis but...

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Detalles Bibliográficos
Autores principales: Liu, Fangming, Gai, Xiaochen, Wu, Yuting, Zhang, Baohui, Wu, Xiaoyu, Cheng, Rongrong, Tang, Bufu, Shang, Kezhuo, Zhao, Na, Deng, Weiwei, Chen, Jie, Zhang, Zhengyi, Gu, Song, Zheng, Liang, Zhang, Hongbing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9522414/
https://www.ncbi.nlm.nih.gov/pubmed/36122209
http://dx.doi.org/10.1073/pnas.2202157119

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