The Effectiveness of Low Dead Space Syringes for Reducing the Risk of Hepatitis C Virus Acquisition Among People Who Inject Drugs: Findings From a National Survey in England, Wales, and Northern Ireland( )

Syringes with attached needles (termed fixed low dead space syringes [LDSS]) retain less blood following injection than syringes with detachable needles, but evidence on them reducing blood-borne virus transmission among people who inject drugs (PWID) is lacking. Utilizing the UK Unlinked Anonymous...

Descripción completa

Detalles Bibliográficos
Autores principales: Trickey, Adam, Croxford, Sara, Emanuel, Eva, Ijaz, Samreen, Hickman, Matthew, Kesten, Joanna, Thomas, Clare, Edmundson, Claire, Desai, Monica, Vickerman, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9522423/
https://www.ncbi.nlm.nih.gov/pubmed/35184173
http://dx.doi.org/10.1093/cid/ciac140
_version_ 1784800063053103104
author Trickey, Adam
Croxford, Sara
Emanuel, Eva
Ijaz, Samreen
Hickman, Matthew
Kesten, Joanna
Thomas, Clare
Edmundson, Claire
Desai, Monica
Vickerman, Peter
author_facet Trickey, Adam
Croxford, Sara
Emanuel, Eva
Ijaz, Samreen
Hickman, Matthew
Kesten, Joanna
Thomas, Clare
Edmundson, Claire
Desai, Monica
Vickerman, Peter
author_sort Trickey, Adam
collection PubMed
description Syringes with attached needles (termed fixed low dead space syringes [LDSS]) retain less blood following injection than syringes with detachable needles, but evidence on them reducing blood-borne virus transmission among people who inject drugs (PWID) is lacking. Utilizing the UK Unlinked Anonymous Monitoring cross-sectional bio-behavioral surveys among PWID for 2016/18/19 (n = 1429), we showed that always using fixed LDSS was associated with 76% lower likelihood (adjusted odds ratio  = 0.24, 95% confidence interval [CI]: .08–.67) of recent hepatitis C virus infection (RNA-positive and antibody-negative) among antibody-negative PWID compared to using any syringes with detachable needles.
format Online
Article
Text
id pubmed-9522423
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-95224232022-10-03 The Effectiveness of Low Dead Space Syringes for Reducing the Risk of Hepatitis C Virus Acquisition Among People Who Inject Drugs: Findings From a National Survey in England, Wales, and Northern Ireland( ) Trickey, Adam Croxford, Sara Emanuel, Eva Ijaz, Samreen Hickman, Matthew Kesten, Joanna Thomas, Clare Edmundson, Claire Desai, Monica Vickerman, Peter Clin Infect Dis Brief Report Syringes with attached needles (termed fixed low dead space syringes [LDSS]) retain less blood following injection than syringes with detachable needles, but evidence on them reducing blood-borne virus transmission among people who inject drugs (PWID) is lacking. Utilizing the UK Unlinked Anonymous Monitoring cross-sectional bio-behavioral surveys among PWID for 2016/18/19 (n = 1429), we showed that always using fixed LDSS was associated with 76% lower likelihood (adjusted odds ratio  = 0.24, 95% confidence interval [CI]: .08–.67) of recent hepatitis C virus infection (RNA-positive and antibody-negative) among antibody-negative PWID compared to using any syringes with detachable needles. Oxford University Press 2022-02-20 /pmc/articles/PMC9522423/ /pubmed/35184173 http://dx.doi.org/10.1093/cid/ciac140 Text en © The Author(s) 2022. Published by Oxford University Press for the Infectious Diseases Society of America. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Report
Trickey, Adam
Croxford, Sara
Emanuel, Eva
Ijaz, Samreen
Hickman, Matthew
Kesten, Joanna
Thomas, Clare
Edmundson, Claire
Desai, Monica
Vickerman, Peter
The Effectiveness of Low Dead Space Syringes for Reducing the Risk of Hepatitis C Virus Acquisition Among People Who Inject Drugs: Findings From a National Survey in England, Wales, and Northern Ireland( )
title The Effectiveness of Low Dead Space Syringes for Reducing the Risk of Hepatitis C Virus Acquisition Among People Who Inject Drugs: Findings From a National Survey in England, Wales, and Northern Ireland( )
title_full The Effectiveness of Low Dead Space Syringes for Reducing the Risk of Hepatitis C Virus Acquisition Among People Who Inject Drugs: Findings From a National Survey in England, Wales, and Northern Ireland( )
title_fullStr The Effectiveness of Low Dead Space Syringes for Reducing the Risk of Hepatitis C Virus Acquisition Among People Who Inject Drugs: Findings From a National Survey in England, Wales, and Northern Ireland( )
title_full_unstemmed The Effectiveness of Low Dead Space Syringes for Reducing the Risk of Hepatitis C Virus Acquisition Among People Who Inject Drugs: Findings From a National Survey in England, Wales, and Northern Ireland( )
title_short The Effectiveness of Low Dead Space Syringes for Reducing the Risk of Hepatitis C Virus Acquisition Among People Who Inject Drugs: Findings From a National Survey in England, Wales, and Northern Ireland( )
title_sort effectiveness of low dead space syringes for reducing the risk of hepatitis c virus acquisition among people who inject drugs: findings from a national survey in england, wales, and northern ireland( )
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9522423/
https://www.ncbi.nlm.nih.gov/pubmed/35184173
http://dx.doi.org/10.1093/cid/ciac140
work_keys_str_mv AT trickeyadam theeffectivenessoflowdeadspacesyringesforreducingtheriskofhepatitiscvirusacquisitionamongpeoplewhoinjectdrugsfindingsfromanationalsurveyinenglandwalesandnorthernireland
AT croxfordsara theeffectivenessoflowdeadspacesyringesforreducingtheriskofhepatitiscvirusacquisitionamongpeoplewhoinjectdrugsfindingsfromanationalsurveyinenglandwalesandnorthernireland
AT emanueleva theeffectivenessoflowdeadspacesyringesforreducingtheriskofhepatitiscvirusacquisitionamongpeoplewhoinjectdrugsfindingsfromanationalsurveyinenglandwalesandnorthernireland
AT ijazsamreen theeffectivenessoflowdeadspacesyringesforreducingtheriskofhepatitiscvirusacquisitionamongpeoplewhoinjectdrugsfindingsfromanationalsurveyinenglandwalesandnorthernireland
AT hickmanmatthew theeffectivenessoflowdeadspacesyringesforreducingtheriskofhepatitiscvirusacquisitionamongpeoplewhoinjectdrugsfindingsfromanationalsurveyinenglandwalesandnorthernireland
AT kestenjoanna theeffectivenessoflowdeadspacesyringesforreducingtheriskofhepatitiscvirusacquisitionamongpeoplewhoinjectdrugsfindingsfromanationalsurveyinenglandwalesandnorthernireland
AT thomasclare theeffectivenessoflowdeadspacesyringesforreducingtheriskofhepatitiscvirusacquisitionamongpeoplewhoinjectdrugsfindingsfromanationalsurveyinenglandwalesandnorthernireland
AT edmundsonclaire theeffectivenessoflowdeadspacesyringesforreducingtheriskofhepatitiscvirusacquisitionamongpeoplewhoinjectdrugsfindingsfromanationalsurveyinenglandwalesandnorthernireland
AT desaimonica theeffectivenessoflowdeadspacesyringesforreducingtheriskofhepatitiscvirusacquisitionamongpeoplewhoinjectdrugsfindingsfromanationalsurveyinenglandwalesandnorthernireland
AT vickermanpeter theeffectivenessoflowdeadspacesyringesforreducingtheriskofhepatitiscvirusacquisitionamongpeoplewhoinjectdrugsfindingsfromanationalsurveyinenglandwalesandnorthernireland
AT trickeyadam effectivenessoflowdeadspacesyringesforreducingtheriskofhepatitiscvirusacquisitionamongpeoplewhoinjectdrugsfindingsfromanationalsurveyinenglandwalesandnorthernireland
AT croxfordsara effectivenessoflowdeadspacesyringesforreducingtheriskofhepatitiscvirusacquisitionamongpeoplewhoinjectdrugsfindingsfromanationalsurveyinenglandwalesandnorthernireland
AT emanueleva effectivenessoflowdeadspacesyringesforreducingtheriskofhepatitiscvirusacquisitionamongpeoplewhoinjectdrugsfindingsfromanationalsurveyinenglandwalesandnorthernireland
AT ijazsamreen effectivenessoflowdeadspacesyringesforreducingtheriskofhepatitiscvirusacquisitionamongpeoplewhoinjectdrugsfindingsfromanationalsurveyinenglandwalesandnorthernireland
AT hickmanmatthew effectivenessoflowdeadspacesyringesforreducingtheriskofhepatitiscvirusacquisitionamongpeoplewhoinjectdrugsfindingsfromanationalsurveyinenglandwalesandnorthernireland
AT kestenjoanna effectivenessoflowdeadspacesyringesforreducingtheriskofhepatitiscvirusacquisitionamongpeoplewhoinjectdrugsfindingsfromanationalsurveyinenglandwalesandnorthernireland
AT thomasclare effectivenessoflowdeadspacesyringesforreducingtheriskofhepatitiscvirusacquisitionamongpeoplewhoinjectdrugsfindingsfromanationalsurveyinenglandwalesandnorthernireland
AT edmundsonclaire effectivenessoflowdeadspacesyringesforreducingtheriskofhepatitiscvirusacquisitionamongpeoplewhoinjectdrugsfindingsfromanationalsurveyinenglandwalesandnorthernireland
AT desaimonica effectivenessoflowdeadspacesyringesforreducingtheriskofhepatitiscvirusacquisitionamongpeoplewhoinjectdrugsfindingsfromanationalsurveyinenglandwalesandnorthernireland
AT vickermanpeter effectivenessoflowdeadspacesyringesforreducingtheriskofhepatitiscvirusacquisitionamongpeoplewhoinjectdrugsfindingsfromanationalsurveyinenglandwalesandnorthernireland

Ejemplares similares