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The Genomic Architecture of Pregnancy-Associated Plasticity in the Maternal Mouse Hippocampus
Pregnancy is associated with extraordinary plasticity in the maternal brain. Studies in humans and other mammals suggest extensive structural and functional remodeling of the female brain during and after pregnancy. However, we understand remarkably little about the molecular underpinnings of this n...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Society for Neuroscience
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9522463/ https://www.ncbi.nlm.nih.gov/pubmed/36239981 http://dx.doi.org/10.1523/ENEURO.0117-22.2022 |
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author | Celik, Alper Somer, Max Kukreja, Bharti Wu, Taiyi Kalish, Brian T. |
author_facet | Celik, Alper Somer, Max Kukreja, Bharti Wu, Taiyi Kalish, Brian T. |
author_sort | Celik, Alper |
collection | PubMed |
description | Pregnancy is associated with extraordinary plasticity in the maternal brain. Studies in humans and other mammals suggest extensive structural and functional remodeling of the female brain during and after pregnancy. However, we understand remarkably little about the molecular underpinnings of this natural phenomenon. To gain insight into pregnancy-associated hippocampal plasticity, we performed single nucleus RNA sequencing (snRNA-seq) and snATAC-seq from the mouse hippocampus before, during, and after pregnancy. We identified cell type-specific transcriptional and epigenetic signatures associated with pregnancy and postpartum adaptation. In addition, we analyzed receptor-ligand interactions and transcription factor (TF) motifs that inform hippocampal cell type identity and provide evidence of pregnancy-associated adaption. In total, these data provide a unique resource of coupled transcriptional and epigenetic data across a dynamic time period in the mouse hippocampus and suggest opportunities for functional interrogation of hormone-mediated plasticity. |
format | Online Article Text |
id | pubmed-9522463 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Society for Neuroscience |
record_format | MEDLINE/PubMed |
spelling | pubmed-95224632022-09-30 The Genomic Architecture of Pregnancy-Associated Plasticity in the Maternal Mouse Hippocampus Celik, Alper Somer, Max Kukreja, Bharti Wu, Taiyi Kalish, Brian T. eNeuro Research Article: New Research Pregnancy is associated with extraordinary plasticity in the maternal brain. Studies in humans and other mammals suggest extensive structural and functional remodeling of the female brain during and after pregnancy. However, we understand remarkably little about the molecular underpinnings of this natural phenomenon. To gain insight into pregnancy-associated hippocampal plasticity, we performed single nucleus RNA sequencing (snRNA-seq) and snATAC-seq from the mouse hippocampus before, during, and after pregnancy. We identified cell type-specific transcriptional and epigenetic signatures associated with pregnancy and postpartum adaptation. In addition, we analyzed receptor-ligand interactions and transcription factor (TF) motifs that inform hippocampal cell type identity and provide evidence of pregnancy-associated adaption. In total, these data provide a unique resource of coupled transcriptional and epigenetic data across a dynamic time period in the mouse hippocampus and suggest opportunities for functional interrogation of hormone-mediated plasticity. Society for Neuroscience 2022-09-21 /pmc/articles/PMC9522463/ /pubmed/36239981 http://dx.doi.org/10.1523/ENEURO.0117-22.2022 Text en Copyright © 2022 Celik et al. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. |
spellingShingle | Research Article: New Research Celik, Alper Somer, Max Kukreja, Bharti Wu, Taiyi Kalish, Brian T. The Genomic Architecture of Pregnancy-Associated Plasticity in the Maternal Mouse Hippocampus |
title | The Genomic Architecture of Pregnancy-Associated Plasticity in the Maternal Mouse Hippocampus |
title_full | The Genomic Architecture of Pregnancy-Associated Plasticity in the Maternal Mouse Hippocampus |
title_fullStr | The Genomic Architecture of Pregnancy-Associated Plasticity in the Maternal Mouse Hippocampus |
title_full_unstemmed | The Genomic Architecture of Pregnancy-Associated Plasticity in the Maternal Mouse Hippocampus |
title_short | The Genomic Architecture of Pregnancy-Associated Plasticity in the Maternal Mouse Hippocampus |
title_sort | genomic architecture of pregnancy-associated plasticity in the maternal mouse hippocampus |
topic | Research Article: New Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9522463/ https://www.ncbi.nlm.nih.gov/pubmed/36239981 http://dx.doi.org/10.1523/ENEURO.0117-22.2022 |
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