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Translatome proteomics identifies autophagy as a resistance mechanism to on-target FLT3 inhibitors in acute myeloid leukemia

Internal tandem duplications (ITD) in the receptor tyrosine kinase FLT3 occur in 25 % of acute myeloid leukemia (AML) patients, drive leukemia progression and confer a poor prognosis. Primary resistance to FLT3 kinase inhibitors (FLT3i) quizartinib, crenolanib and gilteritinib is a frequent clinical...

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Detalles Bibliográficos
Autores principales:	Koschade, Sebastian E., Klann, Kevin, Shaid, Shabnam, Vick, Binje, Stratmann, Jan A., Thölken, Marlyn, Meyer, Laura M., Nguyen, The Duy, Campe, Julia, Moser, Laura M., Hock, Susanna, Baker, Fatima, Meyer, Christian T., Wempe, Frank, Serve, Hubert, Ullrich, Evelyn, Jeremias, Irmela, Münch, Christian, Brandts, Christian H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9522593/ https://www.ncbi.nlm.nih.gov/pubmed/35999260 http://dx.doi.org/10.1038/s41375-022-01678-y

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