Concentration of cephalothin in body fluids and tissue samples of Thoroughbred horses

Cephalothin (CET) concentrations in body fluids (plasma, synovial fluid, pleural fluid, peritoneal fluid, and aqueous humor) and tissue samples (bone, lung, jejunum, hoof, and subcutaneous tissue) were investigated to consider the treatment of infectious diseases in horses. CET 22 mg/kg body weight...

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Autores principales: KURODA, Taisuke, MINAMIJIMA, Yohei, NIWA, Hidekazu, MITA, Hiroshi, TAMURA, Norihisa, FUKUDA, Kentaro, KUWANO, Atsutoshi, SATO, Fumio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Equine Science 2022
Materias:
Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9522621/
https://www.ncbi.nlm.nih.gov/pubmed/36196140
http://dx.doi.org/10.1294/jes.33.51
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author KURODA, Taisuke
MINAMIJIMA, Yohei
NIWA, Hidekazu
MITA, Hiroshi
TAMURA, Norihisa
FUKUDA, Kentaro
KUWANO, Atsutoshi
SATO, Fumio
author_facet KURODA, Taisuke
MINAMIJIMA, Yohei
NIWA, Hidekazu
MITA, Hiroshi
TAMURA, Norihisa
FUKUDA, Kentaro
KUWANO, Atsutoshi
SATO, Fumio
author_sort KURODA, Taisuke
collection PubMed
description Cephalothin (CET) concentrations in body fluids (plasma, synovial fluid, pleural fluid, peritoneal fluid, and aqueous humor) and tissue samples (bone, lung, jejunum, hoof, and subcutaneous tissue) were investigated to consider the treatment of infectious diseases in horses. CET 22 mg/kg body weight was intravenously administered to 12 horses. Samples were collected from four different horses at 1, 3, and 5 hr after administration. The CET concentration in body fluids other than aqueous humor was maintained above the MIC(90) values of Streptococcus zooepidemicus and Staphylococcus aureus until 5 hr, but it was not maintained above that of S. aureus in bone. CET (22 mg/kg twice a day) is effective for septic arthritis, pleuritis, and peritonitis caused by gram-positive bacteria but ineffective for osteomyelitis.
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spelling pubmed-95226212022-10-03 Concentration of cephalothin in body fluids and tissue samples of Thoroughbred horses KURODA, Taisuke MINAMIJIMA, Yohei NIWA, Hidekazu MITA, Hiroshi TAMURA, Norihisa FUKUDA, Kentaro KUWANO, Atsutoshi SATO, Fumio J Equine Sci Note Cephalothin (CET) concentrations in body fluids (plasma, synovial fluid, pleural fluid, peritoneal fluid, and aqueous humor) and tissue samples (bone, lung, jejunum, hoof, and subcutaneous tissue) were investigated to consider the treatment of infectious diseases in horses. CET 22 mg/kg body weight was intravenously administered to 12 horses. Samples were collected from four different horses at 1, 3, and 5 hr after administration. The CET concentration in body fluids other than aqueous humor was maintained above the MIC(90) values of Streptococcus zooepidemicus and Staphylococcus aureus until 5 hr, but it was not maintained above that of S. aureus in bone. CET (22 mg/kg twice a day) is effective for septic arthritis, pleuritis, and peritonitis caused by gram-positive bacteria but ineffective for osteomyelitis. The Japanese Society of Equine Science 2022-09-21 2022-09 /pmc/articles/PMC9522621/ /pubmed/36196140 http://dx.doi.org/10.1294/jes.33.51 Text en ©2022 The Japanese Society of Equine Science https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Note
KURODA, Taisuke
MINAMIJIMA, Yohei
NIWA, Hidekazu
MITA, Hiroshi
TAMURA, Norihisa
FUKUDA, Kentaro
KUWANO, Atsutoshi
SATO, Fumio
Concentration of cephalothin in body fluids and tissue samples of Thoroughbred horses
title Concentration of cephalothin in body fluids and tissue samples of Thoroughbred horses
title_full Concentration of cephalothin in body fluids and tissue samples of Thoroughbred horses
title_fullStr Concentration of cephalothin in body fluids and tissue samples of Thoroughbred horses
title_full_unstemmed Concentration of cephalothin in body fluids and tissue samples of Thoroughbred horses
title_short Concentration of cephalothin in body fluids and tissue samples of Thoroughbred horses
title_sort concentration of cephalothin in body fluids and tissue samples of thoroughbred horses
topic Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9522621/
https://www.ncbi.nlm.nih.gov/pubmed/36196140
http://dx.doi.org/10.1294/jes.33.51
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