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Precision medicine in type 1 diabetes
First envisioned by early diabetes clinicians, a person-centred approach to care was an aspirational goal that aimed to match insulin therapy to each individual’s unique requirements. In the 100 years since the discovery of insulin, this goal has evolved to include personalised approaches to type 1...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9522741/ https://www.ncbi.nlm.nih.gov/pubmed/35994083 http://dx.doi.org/10.1007/s00125-022-05778-3 |
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author | Carr, Alice L. J. Evans-Molina, Carmella Oram, Richard A. |
author_facet | Carr, Alice L. J. Evans-Molina, Carmella Oram, Richard A. |
author_sort | Carr, Alice L. J. |
collection | PubMed |
description | First envisioned by early diabetes clinicians, a person-centred approach to care was an aspirational goal that aimed to match insulin therapy to each individual’s unique requirements. In the 100 years since the discovery of insulin, this goal has evolved to include personalised approaches to type 1 diabetes diagnosis, treatment, prevention and prediction. These advances have been facilitated by the recognition of type 1 diabetes as an autoimmune disease and by advances in our understanding of diabetes pathophysiology, genetics and natural history, which have occurred in parallel with advancements in insulin delivery, glucose monitoring and tools for self-management. In this review, we discuss how these personalised approaches have improved diabetes care and how improved understanding of pathogenesis and human biology might inform precision medicine in the future. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains a slideset of the figures for download available at 10.1007/s00125-022-05778-3. |
format | Online Article Text |
id | pubmed-9522741 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-95227412022-10-01 Precision medicine in type 1 diabetes Carr, Alice L. J. Evans-Molina, Carmella Oram, Richard A. Diabetologia Review First envisioned by early diabetes clinicians, a person-centred approach to care was an aspirational goal that aimed to match insulin therapy to each individual’s unique requirements. In the 100 years since the discovery of insulin, this goal has evolved to include personalised approaches to type 1 diabetes diagnosis, treatment, prevention and prediction. These advances have been facilitated by the recognition of type 1 diabetes as an autoimmune disease and by advances in our understanding of diabetes pathophysiology, genetics and natural history, which have occurred in parallel with advancements in insulin delivery, glucose monitoring and tools for self-management. In this review, we discuss how these personalised approaches have improved diabetes care and how improved understanding of pathogenesis and human biology might inform precision medicine in the future. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains a slideset of the figures for download available at 10.1007/s00125-022-05778-3. Springer Berlin Heidelberg 2022-08-22 2022 /pmc/articles/PMC9522741/ /pubmed/35994083 http://dx.doi.org/10.1007/s00125-022-05778-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Carr, Alice L. J. Evans-Molina, Carmella Oram, Richard A. Precision medicine in type 1 diabetes |
title | Precision medicine in type 1 diabetes |
title_full | Precision medicine in type 1 diabetes |
title_fullStr | Precision medicine in type 1 diabetes |
title_full_unstemmed | Precision medicine in type 1 diabetes |
title_short | Precision medicine in type 1 diabetes |
title_sort | precision medicine in type 1 diabetes |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9522741/ https://www.ncbi.nlm.nih.gov/pubmed/35994083 http://dx.doi.org/10.1007/s00125-022-05778-3 |
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