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Exercise and Exercise Mimetics for the Treatment of Musculoskeletal Disorders
PURPOSE OF REVIEW: The incidence of musculoskeletal disorders affecting bones, joints, and muscles is dramatically increasing in parallel with the increased longevity of the worldwide population, severely impacting on the individual’s quality of life and on the healthcare costs. Inactivity and seden...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9522759/ https://www.ncbi.nlm.nih.gov/pubmed/35881303 http://dx.doi.org/10.1007/s11914-022-00739-6 |
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author | Cento, Alessia S. Leigheb, Massimiliano Caretti, Giuseppina Penna, Fabio |
author_facet | Cento, Alessia S. Leigheb, Massimiliano Caretti, Giuseppina Penna, Fabio |
author_sort | Cento, Alessia S. |
collection | PubMed |
description | PURPOSE OF REVIEW: The incidence of musculoskeletal disorders affecting bones, joints, and muscles is dramatically increasing in parallel with the increased longevity of the worldwide population, severely impacting on the individual’s quality of life and on the healthcare costs. Inactivity and sedentary lifestyle are nowadays considered the main drivers of age-associated musculoskeletal disorders and exercise may counteract such alterations also in other bone- and muscle-centered disorders. This review aims at clarifying the potential use of exercise training to improve musculoskeletal health. RECENT FINDINGS: Both the skeletal muscle and the bone are involved in a complex crosstalk determining, in part through tissue-specific and inflammatory/immune released factors, the occurrence of musculoskeletal disorders. Exercise is able to modulate the levels of those molecules and several associated molecular pathways. SUMMARY: Evidence from preclinical and clinical trials supports the adoption of exercise and the future use of exercise mimicking drugs will optimize the care of individuals with musculoskeletal disorders. |
format | Online Article Text |
id | pubmed-9522759 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-95227592022-10-01 Exercise and Exercise Mimetics for the Treatment of Musculoskeletal Disorders Cento, Alessia S. Leigheb, Massimiliano Caretti, Giuseppina Penna, Fabio Curr Osteoporos Rep Muscle and Bone (A Bonetto and M Brotto, Section Editors) PURPOSE OF REVIEW: The incidence of musculoskeletal disorders affecting bones, joints, and muscles is dramatically increasing in parallel with the increased longevity of the worldwide population, severely impacting on the individual’s quality of life and on the healthcare costs. Inactivity and sedentary lifestyle are nowadays considered the main drivers of age-associated musculoskeletal disorders and exercise may counteract such alterations also in other bone- and muscle-centered disorders. This review aims at clarifying the potential use of exercise training to improve musculoskeletal health. RECENT FINDINGS: Both the skeletal muscle and the bone are involved in a complex crosstalk determining, in part through tissue-specific and inflammatory/immune released factors, the occurrence of musculoskeletal disorders. Exercise is able to modulate the levels of those molecules and several associated molecular pathways. SUMMARY: Evidence from preclinical and clinical trials supports the adoption of exercise and the future use of exercise mimicking drugs will optimize the care of individuals with musculoskeletal disorders. Springer US 2022-07-26 2022 /pmc/articles/PMC9522759/ /pubmed/35881303 http://dx.doi.org/10.1007/s11914-022-00739-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Muscle and Bone (A Bonetto and M Brotto, Section Editors) Cento, Alessia S. Leigheb, Massimiliano Caretti, Giuseppina Penna, Fabio Exercise and Exercise Mimetics for the Treatment of Musculoskeletal Disorders |
title | Exercise and Exercise Mimetics for the Treatment of Musculoskeletal Disorders |
title_full | Exercise and Exercise Mimetics for the Treatment of Musculoskeletal Disorders |
title_fullStr | Exercise and Exercise Mimetics for the Treatment of Musculoskeletal Disorders |
title_full_unstemmed | Exercise and Exercise Mimetics for the Treatment of Musculoskeletal Disorders |
title_short | Exercise and Exercise Mimetics for the Treatment of Musculoskeletal Disorders |
title_sort | exercise and exercise mimetics for the treatment of musculoskeletal disorders |
topic | Muscle and Bone (A Bonetto and M Brotto, Section Editors) |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9522759/ https://www.ncbi.nlm.nih.gov/pubmed/35881303 http://dx.doi.org/10.1007/s11914-022-00739-6 |
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