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A functional neuroimaging study of self-other processing alterations in atypical developmental trajectories of psychotic-like experiences
Self-disturbances constitute a hallmark of psychosis, but it remains unclear whether these alterations are present in at-risk populations, and therefore their role in the development of psychosis has yet to be confirmed. The present study addressed this question by measuring neural correlates of sel...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9522794/ https://www.ncbi.nlm.nih.gov/pubmed/36175570 http://dx.doi.org/10.1038/s41598-022-20129-3 |
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author | Assaf, Roxane Ouellet, Julien Bourque, Josiane Stip, Emmanuel Leyton, Marco Conrod, Patricia Potvin, Stéphane |
author_facet | Assaf, Roxane Ouellet, Julien Bourque, Josiane Stip, Emmanuel Leyton, Marco Conrod, Patricia Potvin, Stéphane |
author_sort | Assaf, Roxane |
collection | PubMed |
description | Self-disturbances constitute a hallmark of psychosis, but it remains unclear whether these alterations are present in at-risk populations, and therefore their role in the development of psychosis has yet to be confirmed. The present study addressed this question by measuring neural correlates of self-other processing in youth belonging to three developmental trajectories of psychotic experiences. Eighty-six youths were recruited from a longitudinal cohort of over 3800 adolescents based on their trajectories of Psychotic-Like Experiences from 12 to 16 years of age. Participants underwent neuroimaging at 17 years of age (mean). A functional neuroimaging task evaluating self- and other-related trait judgments was used to measure whole-brain activation and connectivity. Youth who showed an increasing trajectory displayed hypoactivation of the dorsomedial prefrontal cortex and hypoconnectivity with the cerebellum. By contrast, youth who showed a decreasing trajectory displayed decreased activation of the superior temporal gyrus, the inferior frontal gyrus, and the middle occipital gyrus. These findings suggest that the increasing trajectory is associated with alterations that might erode distinctions between self and other, influencing the emergence of symptoms such as hallucinations. The decreasing trajectory, in comparison, was associated with hypoactivations in areas influencing attention and basic information processing more generally. These alterations might affect the trajectories’ susceptibilities to positive vs. negative symptoms, respectively. |
format | Online Article Text |
id | pubmed-9522794 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-95227942022-10-01 A functional neuroimaging study of self-other processing alterations in atypical developmental trajectories of psychotic-like experiences Assaf, Roxane Ouellet, Julien Bourque, Josiane Stip, Emmanuel Leyton, Marco Conrod, Patricia Potvin, Stéphane Sci Rep Article Self-disturbances constitute a hallmark of psychosis, but it remains unclear whether these alterations are present in at-risk populations, and therefore their role in the development of psychosis has yet to be confirmed. The present study addressed this question by measuring neural correlates of self-other processing in youth belonging to three developmental trajectories of psychotic experiences. Eighty-six youths were recruited from a longitudinal cohort of over 3800 adolescents based on their trajectories of Psychotic-Like Experiences from 12 to 16 years of age. Participants underwent neuroimaging at 17 years of age (mean). A functional neuroimaging task evaluating self- and other-related trait judgments was used to measure whole-brain activation and connectivity. Youth who showed an increasing trajectory displayed hypoactivation of the dorsomedial prefrontal cortex and hypoconnectivity with the cerebellum. By contrast, youth who showed a decreasing trajectory displayed decreased activation of the superior temporal gyrus, the inferior frontal gyrus, and the middle occipital gyrus. These findings suggest that the increasing trajectory is associated with alterations that might erode distinctions between self and other, influencing the emergence of symptoms such as hallucinations. The decreasing trajectory, in comparison, was associated with hypoactivations in areas influencing attention and basic information processing more generally. These alterations might affect the trajectories’ susceptibilities to positive vs. negative symptoms, respectively. Nature Publishing Group UK 2022-09-29 /pmc/articles/PMC9522794/ /pubmed/36175570 http://dx.doi.org/10.1038/s41598-022-20129-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Assaf, Roxane Ouellet, Julien Bourque, Josiane Stip, Emmanuel Leyton, Marco Conrod, Patricia Potvin, Stéphane A functional neuroimaging study of self-other processing alterations in atypical developmental trajectories of psychotic-like experiences |
title | A functional neuroimaging study of self-other processing alterations in atypical developmental trajectories of psychotic-like experiences |
title_full | A functional neuroimaging study of self-other processing alterations in atypical developmental trajectories of psychotic-like experiences |
title_fullStr | A functional neuroimaging study of self-other processing alterations in atypical developmental trajectories of psychotic-like experiences |
title_full_unstemmed | A functional neuroimaging study of self-other processing alterations in atypical developmental trajectories of psychotic-like experiences |
title_short | A functional neuroimaging study of self-other processing alterations in atypical developmental trajectories of psychotic-like experiences |
title_sort | functional neuroimaging study of self-other processing alterations in atypical developmental trajectories of psychotic-like experiences |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9522794/ https://www.ncbi.nlm.nih.gov/pubmed/36175570 http://dx.doi.org/10.1038/s41598-022-20129-3 |
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