Protein structural transitions critically transform the network connectivity and viscoelasticity of RNA-binding protein condensates but RNA can prevent it

Biomolecular condensates, some of which are liquid-like during health, can age over time becoming gel-like pathological systems. One potential source of loss of liquid-like properties during ageing of RNA-binding protein condensates is the progressive formation of inter-protein β-sheets. To bridge m...

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Detalles Bibliográficos
Autores principales: Tejedor, Andres R., Sanchez-Burgos, Ignacio, Estevez-Espinosa, Maria, Garaizar, Adiran, Collepardo-Guevara, Rosana, Ramirez, Jorge, Espinosa, Jorge R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9522849/
https://www.ncbi.nlm.nih.gov/pubmed/36175408
http://dx.doi.org/10.1038/s41467-022-32874-0

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