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Case report: Atypical anaphylactic reaction to Patent Blue V dye during breast cancer surgery

The most common causes of perioperative hypersensitive reactions are neuromuscular blocking drugs, latex, and antibiotics, although there are other more emerging causative agents. Allergic reactions to Patent Blue V (PBV) dye have been reported. Most of them are mild and presented with blue colorati...

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Autores principales: Misir Šitum, Stanka, Korečić Zrinjščak, Iva, Pečvarac, Maja, Šoštar, Andrea, Žaja, Ana, Tot, Tea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9523237/
https://www.ncbi.nlm.nih.gov/pubmed/36185281
http://dx.doi.org/10.3389/fonc.2022.979393
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author Misir Šitum, Stanka
Korečić Zrinjščak, Iva
Pečvarac, Maja
Šoštar, Andrea
Žaja, Ana
Tot, Tea
author_facet Misir Šitum, Stanka
Korečić Zrinjščak, Iva
Pečvarac, Maja
Šoštar, Andrea
Žaja, Ana
Tot, Tea
author_sort Misir Šitum, Stanka
collection PubMed
description The most common causes of perioperative hypersensitive reactions are neuromuscular blocking drugs, latex, and antibiotics, although there are other more emerging causative agents. Allergic reactions to Patent Blue V (PBV) dye have been reported. Most of them are mild and presented with blue coloration of cutaneous plaque. The PBV dye is widely used in the identification of sentinel lymph nodes in patients with breast cancer and other malignancies. Here, we present a case of 33-year-old patient with carcinoma of the breast proposed for sentinel lymph node and skin-sparing mastectomy with severe, life-threatening anaphylaxis which occurred immediately after PBV dye was injected, with cardiopulmonal resuscitation and prolonged refractory hypotension. The patient was without previous exposure to PBV and signs of skin rash, erythema, or bronchospasm, making the diagnosis and management of such cases challenging. Skin tests were performed on all drugs used in premedication and induction of anesthesia and PBV showed positive at IDT of 1:10. Physicians must always think of possible adverse reaction to PBV and for the potential risk of anaphylactic reaction immediately after the dye is injected, during anesthesia and other procedures.
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spelling pubmed-95232372022-10-01 Case report: Atypical anaphylactic reaction to Patent Blue V dye during breast cancer surgery Misir Šitum, Stanka Korečić Zrinjščak, Iva Pečvarac, Maja Šoštar, Andrea Žaja, Ana Tot, Tea Front Oncol Oncology The most common causes of perioperative hypersensitive reactions are neuromuscular blocking drugs, latex, and antibiotics, although there are other more emerging causative agents. Allergic reactions to Patent Blue V (PBV) dye have been reported. Most of them are mild and presented with blue coloration of cutaneous plaque. The PBV dye is widely used in the identification of sentinel lymph nodes in patients with breast cancer and other malignancies. Here, we present a case of 33-year-old patient with carcinoma of the breast proposed for sentinel lymph node and skin-sparing mastectomy with severe, life-threatening anaphylaxis which occurred immediately after PBV dye was injected, with cardiopulmonal resuscitation and prolonged refractory hypotension. The patient was without previous exposure to PBV and signs of skin rash, erythema, or bronchospasm, making the diagnosis and management of such cases challenging. Skin tests were performed on all drugs used in premedication and induction of anesthesia and PBV showed positive at IDT of 1:10. Physicians must always think of possible adverse reaction to PBV and for the potential risk of anaphylactic reaction immediately after the dye is injected, during anesthesia and other procedures. Frontiers Media S.A. 2022-09-16 /pmc/articles/PMC9523237/ /pubmed/36185281 http://dx.doi.org/10.3389/fonc.2022.979393 Text en Copyright © 2022 Misir Šitum, Korečić Zrinjščak, Pečvarac, Šoštar, Žaja and Tot https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Misir Šitum, Stanka
Korečić Zrinjščak, Iva
Pečvarac, Maja
Šoštar, Andrea
Žaja, Ana
Tot, Tea
Case report: Atypical anaphylactic reaction to Patent Blue V dye during breast cancer surgery
title Case report: Atypical anaphylactic reaction to Patent Blue V dye during breast cancer surgery
title_full Case report: Atypical anaphylactic reaction to Patent Blue V dye during breast cancer surgery
title_fullStr Case report: Atypical anaphylactic reaction to Patent Blue V dye during breast cancer surgery
title_full_unstemmed Case report: Atypical anaphylactic reaction to Patent Blue V dye during breast cancer surgery
title_short Case report: Atypical anaphylactic reaction to Patent Blue V dye during breast cancer surgery
title_sort case report: atypical anaphylactic reaction to patent blue v dye during breast cancer surgery
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9523237/
https://www.ncbi.nlm.nih.gov/pubmed/36185281
http://dx.doi.org/10.3389/fonc.2022.979393
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