Changes in the expression of annexin A1 in the anterior pituitary gland after ovariectomy in rats

The expression of annexin A1 (ANXA1) is augmented by gonadotrophin releasing hormone (GnRH) in LβT2 gonadotroph. We examined the distribution of ANXA1 in the pituitary tissues and the effect of ovariectomy. ANXA1 was mainly stained on folliculostellate cell-like irregular shaped cells with extended...

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Autores principales: FUNGBUN, Numfa, SASAKI, Hiromitsu, TERASHIMA, Ryota, MURATA, Takuya, CHIBA, Shuichi, KURUSU, Shiro, KAWAMINAMI, Mitsumori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2022
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9523297/
https://www.ncbi.nlm.nih.gov/pubmed/35896374
http://dx.doi.org/10.1292/jvms.22-0272
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author FUNGBUN, Numfa
SASAKI, Hiromitsu
TERASHIMA, Ryota
MURATA, Takuya
CHIBA, Shuichi
KURUSU, Shiro
KAWAMINAMI, Mitsumori
author_facet FUNGBUN, Numfa
SASAKI, Hiromitsu
TERASHIMA, Ryota
MURATA, Takuya
CHIBA, Shuichi
KURUSU, Shiro
KAWAMINAMI, Mitsumori
author_sort FUNGBUN, Numfa
collection PubMed
description The expression of annexin A1 (ANXA1) is augmented by gonadotrophin releasing hormone (GnRH) in LβT2 gonadotroph. We examined the distribution of ANXA1 in the pituitary tissues and the effect of ovariectomy. ANXA1 was mainly stained on folliculostellate cell-like irregular shaped cells with extended process of adult female rats. Large gonadotroph, so called castration cells, appeared two weeks after the ovariectomy. ANXA1 in castration cells exists around cells although another GnRH responsive annexin, ANXA5, was apparent also in the cytoplasm. The pituitary expression of ANXA1 after ovariectomy was significantly higher than intact rats. These difference in tissue distribution of two annexins suggest ANXA1 and ANXA5 bear different physiological function in the gonadotroph under GnRH regulation.
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spelling pubmed-95232972022-10-11 Changes in the expression of annexin A1 in the anterior pituitary gland after ovariectomy in rats FUNGBUN, Numfa SASAKI, Hiromitsu TERASHIMA, Ryota MURATA, Takuya CHIBA, Shuichi KURUSU, Shiro KAWAMINAMI, Mitsumori J Vet Med Sci Physiology The expression of annexin A1 (ANXA1) is augmented by gonadotrophin releasing hormone (GnRH) in LβT2 gonadotroph. We examined the distribution of ANXA1 in the pituitary tissues and the effect of ovariectomy. ANXA1 was mainly stained on folliculostellate cell-like irregular shaped cells with extended process of adult female rats. Large gonadotroph, so called castration cells, appeared two weeks after the ovariectomy. ANXA1 in castration cells exists around cells although another GnRH responsive annexin, ANXA5, was apparent also in the cytoplasm. The pituitary expression of ANXA1 after ovariectomy was significantly higher than intact rats. These difference in tissue distribution of two annexins suggest ANXA1 and ANXA5 bear different physiological function in the gonadotroph under GnRH regulation. The Japanese Society of Veterinary Science 2022-07-26 2022-09 /pmc/articles/PMC9523297/ /pubmed/35896374 http://dx.doi.org/10.1292/jvms.22-0272 Text en ©2022 The Japanese Society of Veterinary Science https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Physiology
FUNGBUN, Numfa
SASAKI, Hiromitsu
TERASHIMA, Ryota
MURATA, Takuya
CHIBA, Shuichi
KURUSU, Shiro
KAWAMINAMI, Mitsumori
Changes in the expression of annexin A1 in the anterior pituitary gland after ovariectomy in rats
title Changes in the expression of annexin A1 in the anterior pituitary gland after ovariectomy in rats
title_full Changes in the expression of annexin A1 in the anterior pituitary gland after ovariectomy in rats
title_fullStr Changes in the expression of annexin A1 in the anterior pituitary gland after ovariectomy in rats
title_full_unstemmed Changes in the expression of annexin A1 in the anterior pituitary gland after ovariectomy in rats
title_short Changes in the expression of annexin A1 in the anterior pituitary gland after ovariectomy in rats
title_sort changes in the expression of annexin a1 in the anterior pituitary gland after ovariectomy in rats
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9523297/
https://www.ncbi.nlm.nih.gov/pubmed/35896374
http://dx.doi.org/10.1292/jvms.22-0272
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