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Lupus nephritis: The regulatory interplay between epigenetic and MicroRNAs

MicroRNAs (miRNAs) are endogenous, small, non-coding RNA molecules that act as epigenetic modifiers to regulate the protein levels of target messenger RNAs without altering their genetic sequences. The highly complex role of miRNAs in the epigenetics of lupus nephritis (LN) is increasingly being rec...

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Detalles Bibliográficos
Autores principales: Xu, Ning, Liu, Jie, Li, Xiangling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9523357/
https://www.ncbi.nlm.nih.gov/pubmed/36187762
http://dx.doi.org/10.3389/fphys.2022.925416
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author Xu, Ning
Liu, Jie
Li, Xiangling
author_facet Xu, Ning
Liu, Jie
Li, Xiangling
author_sort Xu, Ning
collection PubMed
description MicroRNAs (miRNAs) are endogenous, small, non-coding RNA molecules that act as epigenetic modifiers to regulate the protein levels of target messenger RNAs without altering their genetic sequences. The highly complex role of miRNAs in the epigenetics of lupus nephritis (LN) is increasingly being recognized. DNA methylation and histone modifications are focal points of epigenetic research. miRNAs play a critical role in renal development and physiology, and dysregulation may result in abnormal renal cell proliferation, inflammation, and fibrosis of the kidneys in LN. However, epigenetic and miRNA-mediated regulation are not mutually exclusive. Further research has established a link between miRNA expression and epigenetic regulation in various disorders, including LN. This review summarizes the most recent evidence regarding the interaction between miRNAs and epigenetics in LN and highlights potential therapeutic and diagnostic targets.
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spelling pubmed-95233572022-10-01 Lupus nephritis: The regulatory interplay between epigenetic and MicroRNAs Xu, Ning Liu, Jie Li, Xiangling Front Physiol Physiology MicroRNAs (miRNAs) are endogenous, small, non-coding RNA molecules that act as epigenetic modifiers to regulate the protein levels of target messenger RNAs without altering their genetic sequences. The highly complex role of miRNAs in the epigenetics of lupus nephritis (LN) is increasingly being recognized. DNA methylation and histone modifications are focal points of epigenetic research. miRNAs play a critical role in renal development and physiology, and dysregulation may result in abnormal renal cell proliferation, inflammation, and fibrosis of the kidneys in LN. However, epigenetic and miRNA-mediated regulation are not mutually exclusive. Further research has established a link between miRNA expression and epigenetic regulation in various disorders, including LN. This review summarizes the most recent evidence regarding the interaction between miRNAs and epigenetics in LN and highlights potential therapeutic and diagnostic targets. Frontiers Media S.A. 2022-09-16 /pmc/articles/PMC9523357/ /pubmed/36187762 http://dx.doi.org/10.3389/fphys.2022.925416 Text en Copyright © 2022 Xu, Liu and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Xu, Ning
Liu, Jie
Li, Xiangling
Lupus nephritis: The regulatory interplay between epigenetic and MicroRNAs
title Lupus nephritis: The regulatory interplay between epigenetic and MicroRNAs
title_full Lupus nephritis: The regulatory interplay between epigenetic and MicroRNAs
title_fullStr Lupus nephritis: The regulatory interplay between epigenetic and MicroRNAs
title_full_unstemmed Lupus nephritis: The regulatory interplay between epigenetic and MicroRNAs
title_short Lupus nephritis: The regulatory interplay between epigenetic and MicroRNAs
title_sort lupus nephritis: the regulatory interplay between epigenetic and micrornas
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9523357/
https://www.ncbi.nlm.nih.gov/pubmed/36187762
http://dx.doi.org/10.3389/fphys.2022.925416
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