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Lupus nephritis: The regulatory interplay between epigenetic and MicroRNAs
MicroRNAs (miRNAs) are endogenous, small, non-coding RNA molecules that act as epigenetic modifiers to regulate the protein levels of target messenger RNAs without altering their genetic sequences. The highly complex role of miRNAs in the epigenetics of lupus nephritis (LN) is increasingly being rec...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9523357/ https://www.ncbi.nlm.nih.gov/pubmed/36187762 http://dx.doi.org/10.3389/fphys.2022.925416 |
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author | Xu, Ning Liu, Jie Li, Xiangling |
author_facet | Xu, Ning Liu, Jie Li, Xiangling |
author_sort | Xu, Ning |
collection | PubMed |
description | MicroRNAs (miRNAs) are endogenous, small, non-coding RNA molecules that act as epigenetic modifiers to regulate the protein levels of target messenger RNAs without altering their genetic sequences. The highly complex role of miRNAs in the epigenetics of lupus nephritis (LN) is increasingly being recognized. DNA methylation and histone modifications are focal points of epigenetic research. miRNAs play a critical role in renal development and physiology, and dysregulation may result in abnormal renal cell proliferation, inflammation, and fibrosis of the kidneys in LN. However, epigenetic and miRNA-mediated regulation are not mutually exclusive. Further research has established a link between miRNA expression and epigenetic regulation in various disorders, including LN. This review summarizes the most recent evidence regarding the interaction between miRNAs and epigenetics in LN and highlights potential therapeutic and diagnostic targets. |
format | Online Article Text |
id | pubmed-9523357 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95233572022-10-01 Lupus nephritis: The regulatory interplay between epigenetic and MicroRNAs Xu, Ning Liu, Jie Li, Xiangling Front Physiol Physiology MicroRNAs (miRNAs) are endogenous, small, non-coding RNA molecules that act as epigenetic modifiers to regulate the protein levels of target messenger RNAs without altering their genetic sequences. The highly complex role of miRNAs in the epigenetics of lupus nephritis (LN) is increasingly being recognized. DNA methylation and histone modifications are focal points of epigenetic research. miRNAs play a critical role in renal development and physiology, and dysregulation may result in abnormal renal cell proliferation, inflammation, and fibrosis of the kidneys in LN. However, epigenetic and miRNA-mediated regulation are not mutually exclusive. Further research has established a link between miRNA expression and epigenetic regulation in various disorders, including LN. This review summarizes the most recent evidence regarding the interaction between miRNAs and epigenetics in LN and highlights potential therapeutic and diagnostic targets. Frontiers Media S.A. 2022-09-16 /pmc/articles/PMC9523357/ /pubmed/36187762 http://dx.doi.org/10.3389/fphys.2022.925416 Text en Copyright © 2022 Xu, Liu and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Xu, Ning Liu, Jie Li, Xiangling Lupus nephritis: The regulatory interplay between epigenetic and MicroRNAs |
title | Lupus nephritis: The regulatory interplay between epigenetic and MicroRNAs |
title_full | Lupus nephritis: The regulatory interplay between epigenetic and MicroRNAs |
title_fullStr | Lupus nephritis: The regulatory interplay between epigenetic and MicroRNAs |
title_full_unstemmed | Lupus nephritis: The regulatory interplay between epigenetic and MicroRNAs |
title_short | Lupus nephritis: The regulatory interplay between epigenetic and MicroRNAs |
title_sort | lupus nephritis: the regulatory interplay between epigenetic and micrornas |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9523357/ https://www.ncbi.nlm.nih.gov/pubmed/36187762 http://dx.doi.org/10.3389/fphys.2022.925416 |
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