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Cbl-b restrains priming of pathogenic Th17 cells via the inhibition of IL-6 production by macrophages

E3 ubiquitin ligase Cbl-b is involved in the maintenance of a balance between immunity and tolerance. Mice lacking Cbl-b are highly susceptible to experimental autoimmune encephalomyelitis (EAE), a Th17-mediated autoimmune disease. However, how Cbl-b regulates Th17 cell responses remains unclear. In...

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Detalles Bibliográficos
Autores principales:	Zeng, Qiuming, Tang, Na, Ma, Yilei, Guo, Hui, Zhao, Yixia, Tang, Rong, Yan, Chengkai, Ouyang, Song, Langdon, Wallace Y., Yang, Huan, O’Brien, Matthew C., Zhang, Jian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9523381/ https://www.ncbi.nlm.nih.gov/pubmed/36185364 http://dx.doi.org/10.1016/j.isci.2022.105151

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