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Human PSCs determine the competency of cerebral organoid differentiation via FGF signaling and epigenetic mechanisms

Various culture methods have been developed for maintaining human pluripotent stem cells (PSCs). These PSC maintenance methods exhibit biased differentiation; for example, feeder-dependent PSCs efficiently yield cerebral organoids, but it is difficult to generate organoids from feeder-free PSCs. It...

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Detalles Bibliográficos
Autores principales:	Ideno, Hirosato, Imaizumi, Kent, Shimada, Hiroko, Sanosaka, Tsukasa, Nemoto, Akisa, Kohyama, Jun, Okano, Hideyuki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9523398/ https://www.ncbi.nlm.nih.gov/pubmed/36185382 http://dx.doi.org/10.1016/j.isci.2022.105140

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