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Improving the ischemia-reperfusion injury in vascularized composite allotransplantation: Clinical experience and experimental implications

Long-time ischemia worsening transplant outcomes in vascularized composite allotransplantation (VCA) is often neglected. Ischemia-reperfusion injury (IRI) is an inevitable event that follows reperfusion after a period of cold static storage. The pathophysiological mechanism activates local inflammat...

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Autores principales: He, Jiqiang, Khan, Umar Zeb, Qing, Liming, Wu, Panfeng, Tang, Juyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9523406/
https://www.ncbi.nlm.nih.gov/pubmed/36189311
http://dx.doi.org/10.3389/fimmu.2022.998952
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author He, Jiqiang
Khan, Umar Zeb
Qing, Liming
Wu, Panfeng
Tang, Juyu
author_facet He, Jiqiang
Khan, Umar Zeb
Qing, Liming
Wu, Panfeng
Tang, Juyu
author_sort He, Jiqiang
collection PubMed
description Long-time ischemia worsening transplant outcomes in vascularized composite allotransplantation (VCA) is often neglected. Ischemia-reperfusion injury (IRI) is an inevitable event that follows reperfusion after a period of cold static storage. The pathophysiological mechanism activates local inflammation, which is a barrier to allograft long-term immune tolerance. The previous publications have not clearly described the relationship between the tissue damage and ischemia time, nor the rejection grade. In this review, we found that the rejection episodes and rejection grade are usually related to the ischemia time, both in clinical and experimental aspects. Moreover, we summarized the potential therapeutic measures to mitigate the ischemia-reperfusion injury. Compare to static preservation, machine perfusion is a promising method that can keep VCA tissue viability and extend preservation time, which is especially beneficial for the expansion of the donor pool and better MHC-matching.
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spelling pubmed-95234062022-10-01 Improving the ischemia-reperfusion injury in vascularized composite allotransplantation: Clinical experience and experimental implications He, Jiqiang Khan, Umar Zeb Qing, Liming Wu, Panfeng Tang, Juyu Front Immunol Immunology Long-time ischemia worsening transplant outcomes in vascularized composite allotransplantation (VCA) is often neglected. Ischemia-reperfusion injury (IRI) is an inevitable event that follows reperfusion after a period of cold static storage. The pathophysiological mechanism activates local inflammation, which is a barrier to allograft long-term immune tolerance. The previous publications have not clearly described the relationship between the tissue damage and ischemia time, nor the rejection grade. In this review, we found that the rejection episodes and rejection grade are usually related to the ischemia time, both in clinical and experimental aspects. Moreover, we summarized the potential therapeutic measures to mitigate the ischemia-reperfusion injury. Compare to static preservation, machine perfusion is a promising method that can keep VCA tissue viability and extend preservation time, which is especially beneficial for the expansion of the donor pool and better MHC-matching. Frontiers Media S.A. 2022-09-16 /pmc/articles/PMC9523406/ /pubmed/36189311 http://dx.doi.org/10.3389/fimmu.2022.998952 Text en Copyright © 2022 He, Khan, Qing, Wu and Tang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
He, Jiqiang
Khan, Umar Zeb
Qing, Liming
Wu, Panfeng
Tang, Juyu
Improving the ischemia-reperfusion injury in vascularized composite allotransplantation: Clinical experience and experimental implications
title Improving the ischemia-reperfusion injury in vascularized composite allotransplantation: Clinical experience and experimental implications
title_full Improving the ischemia-reperfusion injury in vascularized composite allotransplantation: Clinical experience and experimental implications
title_fullStr Improving the ischemia-reperfusion injury in vascularized composite allotransplantation: Clinical experience and experimental implications
title_full_unstemmed Improving the ischemia-reperfusion injury in vascularized composite allotransplantation: Clinical experience and experimental implications
title_short Improving the ischemia-reperfusion injury in vascularized composite allotransplantation: Clinical experience and experimental implications
title_sort improving the ischemia-reperfusion injury in vascularized composite allotransplantation: clinical experience and experimental implications
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9523406/
https://www.ncbi.nlm.nih.gov/pubmed/36189311
http://dx.doi.org/10.3389/fimmu.2022.998952
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