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RNA-binding protein signaling in adult neurogenesis

The process of neurogenesis in the brain, including cell proliferation, differentiation, survival, and maturation, results in the formation of new functional neurons. During embryonic development, neurogenesis is crucial to produce neurons to establish the nervous system, but the process persists in...

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Autores principales: Chan, Jackie Ngai-Man, Sánchez-Vidaña, Dalinda Isabel, Anoopkumar-Dukie, Shailendra, Li, Yue, Benson Wui-Man, Lau
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9523427/
https://www.ncbi.nlm.nih.gov/pubmed/36187492
http://dx.doi.org/10.3389/fcell.2022.982549
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author Chan, Jackie Ngai-Man
Sánchez-Vidaña, Dalinda Isabel
Anoopkumar-Dukie, Shailendra
Li, Yue
Benson Wui-Man, Lau
author_facet Chan, Jackie Ngai-Man
Sánchez-Vidaña, Dalinda Isabel
Anoopkumar-Dukie, Shailendra
Li, Yue
Benson Wui-Man, Lau
author_sort Chan, Jackie Ngai-Man
collection PubMed
description The process of neurogenesis in the brain, including cell proliferation, differentiation, survival, and maturation, results in the formation of new functional neurons. During embryonic development, neurogenesis is crucial to produce neurons to establish the nervous system, but the process persists in certain brain regions during adulthood. In adult neurogenesis, the production of new neurons in the hippocampus is accomplished via the division of neural stem cells. Neurogenesis is regulated by multiple factors, including gene expression at a temporal scale and post-transcriptional modifications. RNA-binding Proteins (RBPs) are known as proteins that bind to either double- or single-stranded RNA in cells and form ribonucleoprotein complexes. The involvement of RBPs in neurogenesis is crucial for modulating gene expression changes and posttranscriptional processes. Since neurogenesis affects learning and memory, RBPs are closely associated with cognitive functions and emotions. However, the pathways of each RBP in adult neurogenesis remain elusive and not clear. In this review, we specifically summarize the involvement of several RBPs in adult neurogenesis, including CPEB3, FXR2, FMRP, HuR, HuD, Lin28, Msi1, Sam68, Stau1, Smaug2, and SOX2. To understand the role of these RBPs in neurogenesis, including cell proliferation, differentiation, survival, and maturation as well as posttranscriptional gene expression, we discussed the protein family, structure, expression, functional domain, and region of action. Therefore, this narrative review aims to provide a comprehensive overview of the RBPs, their function, and their role in the process of adult neurogenesis as well as to identify possible research directions on RBPs and neurogenesis.
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spelling pubmed-95234272022-10-01 RNA-binding protein signaling in adult neurogenesis Chan, Jackie Ngai-Man Sánchez-Vidaña, Dalinda Isabel Anoopkumar-Dukie, Shailendra Li, Yue Benson Wui-Man, Lau Front Cell Dev Biol Cell and Developmental Biology The process of neurogenesis in the brain, including cell proliferation, differentiation, survival, and maturation, results in the formation of new functional neurons. During embryonic development, neurogenesis is crucial to produce neurons to establish the nervous system, but the process persists in certain brain regions during adulthood. In adult neurogenesis, the production of new neurons in the hippocampus is accomplished via the division of neural stem cells. Neurogenesis is regulated by multiple factors, including gene expression at a temporal scale and post-transcriptional modifications. RNA-binding Proteins (RBPs) are known as proteins that bind to either double- or single-stranded RNA in cells and form ribonucleoprotein complexes. The involvement of RBPs in neurogenesis is crucial for modulating gene expression changes and posttranscriptional processes. Since neurogenesis affects learning and memory, RBPs are closely associated with cognitive functions and emotions. However, the pathways of each RBP in adult neurogenesis remain elusive and not clear. In this review, we specifically summarize the involvement of several RBPs in adult neurogenesis, including CPEB3, FXR2, FMRP, HuR, HuD, Lin28, Msi1, Sam68, Stau1, Smaug2, and SOX2. To understand the role of these RBPs in neurogenesis, including cell proliferation, differentiation, survival, and maturation as well as posttranscriptional gene expression, we discussed the protein family, structure, expression, functional domain, and region of action. Therefore, this narrative review aims to provide a comprehensive overview of the RBPs, their function, and their role in the process of adult neurogenesis as well as to identify possible research directions on RBPs and neurogenesis. Frontiers Media S.A. 2022-09-16 /pmc/articles/PMC9523427/ /pubmed/36187492 http://dx.doi.org/10.3389/fcell.2022.982549 Text en Copyright © 2022 Chan, Sánchez-Vidaña, Anoopkumar-Dukie, Li and Benson Wui-Man. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Chan, Jackie Ngai-Man
Sánchez-Vidaña, Dalinda Isabel
Anoopkumar-Dukie, Shailendra
Li, Yue
Benson Wui-Man, Lau
RNA-binding protein signaling in adult neurogenesis
title RNA-binding protein signaling in adult neurogenesis
title_full RNA-binding protein signaling in adult neurogenesis
title_fullStr RNA-binding protein signaling in adult neurogenesis
title_full_unstemmed RNA-binding protein signaling in adult neurogenesis
title_short RNA-binding protein signaling in adult neurogenesis
title_sort rna-binding protein signaling in adult neurogenesis
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9523427/
https://www.ncbi.nlm.nih.gov/pubmed/36187492
http://dx.doi.org/10.3389/fcell.2022.982549
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