CEPsh glia development is not required for general AWC identity or AWC asymmetry

The Caenorhabditis elegans VAB-3/Pax6 homeodomain protein was previously shown to play a role in both the development of cephalic sheath (CEPsh) glia and asymmetric differentiation of AWC olfactory neuron subtypes AWC (ON) /AWC (OFF) . Here we show that vab-3 is not required for the specification of...

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Autores principales: Xiong, Rui, Hsieh, Yi-Wen, Chuang, Chiou-Fen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Caltech Library 2022
Materias:
New Finding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9523477/
https://www.ncbi.nlm.nih.gov/pubmed/36188097
http://dx.doi.org/10.17912/micropub.biology.000636
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author Xiong, Rui
Hsieh, Yi-Wen
Chuang, Chiou-Fen
author_facet Xiong, Rui
Hsieh, Yi-Wen
Chuang, Chiou-Fen
author_sort Xiong, Rui
collection PubMed
description The Caenorhabditis elegans VAB-3/Pax6 homeodomain protein was previously shown to play a role in both the development of cephalic sheath (CEPsh) glia and asymmetric differentiation of AWC olfactory neuron subtypes AWC (ON) /AWC (OFF) . Here we show that vab-3 is not required for the specification of general AWC identity. We also show that some vab-3 mutant alleles with defective CEPsh glia development displayed wild-type AWC asymmetry. These results suggest that vab-3 has separable roles in CEPsh glia development and AWC asymmetry. Together, our results suggest that general AWC identity and AWC asymmetry are not dependent on the development of CEPsh glia.
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spelling pubmed-95234772022-10-01 CEPsh glia development is not required for general AWC identity or AWC asymmetry Xiong, Rui Hsieh, Yi-Wen Chuang, Chiou-Fen MicroPubl Biol New Finding The Caenorhabditis elegans VAB-3/Pax6 homeodomain protein was previously shown to play a role in both the development of cephalic sheath (CEPsh) glia and asymmetric differentiation of AWC olfactory neuron subtypes AWC (ON) /AWC (OFF) . Here we show that vab-3 is not required for the specification of general AWC identity. We also show that some vab-3 mutant alleles with defective CEPsh glia development displayed wild-type AWC asymmetry. These results suggest that vab-3 has separable roles in CEPsh glia development and AWC asymmetry. Together, our results suggest that general AWC identity and AWC asymmetry are not dependent on the development of CEPsh glia. Caltech Library 2022-09-15 /pmc/articles/PMC9523477/ /pubmed/36188097 http://dx.doi.org/10.17912/micropub.biology.000636 Text en Copyright: © 2022 by the authors https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle New Finding
Xiong, Rui
Hsieh, Yi-Wen
Chuang, Chiou-Fen
CEPsh glia development is not required for general AWC identity or AWC asymmetry
title CEPsh glia development is not required for general AWC identity or AWC asymmetry
title_full CEPsh glia development is not required for general AWC identity or AWC asymmetry
title_fullStr CEPsh glia development is not required for general AWC identity or AWC asymmetry
title_full_unstemmed CEPsh glia development is not required for general AWC identity or AWC asymmetry
title_short CEPsh glia development is not required for general AWC identity or AWC asymmetry
title_sort cepsh glia development is not required for general awc identity or awc asymmetry
topic New Finding
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9523477/
https://www.ncbi.nlm.nih.gov/pubmed/36188097
http://dx.doi.org/10.17912/micropub.biology.000636
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AT hsiehyiwen cepshgliadevelopmentisnotrequiredforgeneralawcidentityorawcasymmetry
AT chuangchioufen cepshgliadevelopmentisnotrequiredforgeneralawcidentityorawcasymmetry

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