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Testicular tumors in the “elderly” population

Germ cell tumors arise in childhood but peak at around 30 years of age. They are the most common cancers in males under the age of 35. Over 95% arise in the testes while a minority originate in extragonadal sites such as the anterior mediastinum, or mainly in childhood the pineal gland or the sacroc...

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Autores principales: Secondino, Simona, Rosti, Giovanni, Tralongo, Antonino C., Nolè, Franco, Alaimo, Domiziana, Carminati, Ornella, Naspro, Richard Lawrence John, Pedrazzoli, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9523537/
https://www.ncbi.nlm.nih.gov/pubmed/36185182
http://dx.doi.org/10.3389/fonc.2022.972151
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author Secondino, Simona
Rosti, Giovanni
Tralongo, Antonino C.
Nolè, Franco
Alaimo, Domiziana
Carminati, Ornella
Naspro, Richard Lawrence John
Pedrazzoli, Paolo
author_facet Secondino, Simona
Rosti, Giovanni
Tralongo, Antonino C.
Nolè, Franco
Alaimo, Domiziana
Carminati, Ornella
Naspro, Richard Lawrence John
Pedrazzoli, Paolo
author_sort Secondino, Simona
collection PubMed
description Germ cell tumors arise in childhood but peak at around 30 years of age. They are the most common cancers in males under the age of 35. Over 95% arise in the testes while a minority originate in extragonadal sites such as the anterior mediastinum, or mainly in childhood the pineal gland or the sacrococcygeal area. These tumors show an extraordinary sensitivity to chemotherapy (and for seminoma, also to radiation) and cure rates are relatively high even in second or subsequent relapses. Very few data are present in the literature regarding patients diagnosed after 50 years and no specific trials have been conducted in this setting. Nearly all patients reported in the literature had testicular cancers, with occasional reports of extragonadal tumors. Despite the fact that > 50 years may be considered an “elderly” population, these patients are treated with the same cisplatin containing combinations as their younger counterparts with consequent higher toxicity. In this review we will present epidemiological and clinical data from this rare population of patients with testicular cancer.
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spelling pubmed-95235372022-10-01 Testicular tumors in the “elderly” population Secondino, Simona Rosti, Giovanni Tralongo, Antonino C. Nolè, Franco Alaimo, Domiziana Carminati, Ornella Naspro, Richard Lawrence John Pedrazzoli, Paolo Front Oncol Oncology Germ cell tumors arise in childhood but peak at around 30 years of age. They are the most common cancers in males under the age of 35. Over 95% arise in the testes while a minority originate in extragonadal sites such as the anterior mediastinum, or mainly in childhood the pineal gland or the sacrococcygeal area. These tumors show an extraordinary sensitivity to chemotherapy (and for seminoma, also to radiation) and cure rates are relatively high even in second or subsequent relapses. Very few data are present in the literature regarding patients diagnosed after 50 years and no specific trials have been conducted in this setting. Nearly all patients reported in the literature had testicular cancers, with occasional reports of extragonadal tumors. Despite the fact that > 50 years may be considered an “elderly” population, these patients are treated with the same cisplatin containing combinations as their younger counterparts with consequent higher toxicity. In this review we will present epidemiological and clinical data from this rare population of patients with testicular cancer. Frontiers Media S.A. 2022-09-16 /pmc/articles/PMC9523537/ /pubmed/36185182 http://dx.doi.org/10.3389/fonc.2022.972151 Text en Copyright © 2022 Secondino, Rosti, Tralongo, Nolè, Alaimo, Carminati, Naspro and Pedrazzoli https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Secondino, Simona
Rosti, Giovanni
Tralongo, Antonino C.
Nolè, Franco
Alaimo, Domiziana
Carminati, Ornella
Naspro, Richard Lawrence John
Pedrazzoli, Paolo
Testicular tumors in the “elderly” population
title Testicular tumors in the “elderly” population
title_full Testicular tumors in the “elderly” population
title_fullStr Testicular tumors in the “elderly” population
title_full_unstemmed Testicular tumors in the “elderly” population
title_short Testicular tumors in the “elderly” population
title_sort testicular tumors in the “elderly” population
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9523537/
https://www.ncbi.nlm.nih.gov/pubmed/36185182
http://dx.doi.org/10.3389/fonc.2022.972151
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