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Resveratrol: A potential therapeutic natural polyphenol for neurodegenerative diseases associated with mitochondrial dysfunction

Most polyphenols can cross blood-brain barrier, therefore, they are widely utilized in the treatment of various neurodegenerative diseases (ND). Resveratrol, a natural polyphenol contained in blueberry, grapes, mulberry, etc., is well documented to exhibit potent neuroprotective activity against dif...

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Autores principales: Yadav, Ekta, Yadav, Pankajkumar, Khan, Mohd Masih Uzzaman, Singh, HariOm, Verma, Amita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9523540/
https://www.ncbi.nlm.nih.gov/pubmed/36188541
http://dx.doi.org/10.3389/fphar.2022.922232
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author Yadav, Ekta
Yadav, Pankajkumar
Khan, Mohd Masih Uzzaman
Singh, HariOm
Verma, Amita
author_facet Yadav, Ekta
Yadav, Pankajkumar
Khan, Mohd Masih Uzzaman
Singh, HariOm
Verma, Amita
author_sort Yadav, Ekta
collection PubMed
description Most polyphenols can cross blood-brain barrier, therefore, they are widely utilized in the treatment of various neurodegenerative diseases (ND). Resveratrol, a natural polyphenol contained in blueberry, grapes, mulberry, etc., is well documented to exhibit potent neuroprotective activity against different ND by mitochondria modulation approach. Mitochondrial function impairment is the most common etiology and pathological process in various neurodegenerative disorders, viz. Alzheimer’s disease, Parkinson’s disease, Huntington’s disease and amyotrophic lateral sclerosis. Nowadays these ND associated with mitochondrial dysfunction have become a major threat to public health as well as health care systems in terms of financial burden. Currently available therapies for ND are limited to symptomatic cures and have inevitable toxic effects. Therefore, there is a strict requirement for a safe and highly effective drug treatment developed from natural compounds. The current review provides updated information about the potential of resveratrol to target mitochondria in the treatment of ND.
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spelling pubmed-95235402022-10-01 Resveratrol: A potential therapeutic natural polyphenol for neurodegenerative diseases associated with mitochondrial dysfunction Yadav, Ekta Yadav, Pankajkumar Khan, Mohd Masih Uzzaman Singh, HariOm Verma, Amita Front Pharmacol Pharmacology Most polyphenols can cross blood-brain barrier, therefore, they are widely utilized in the treatment of various neurodegenerative diseases (ND). Resveratrol, a natural polyphenol contained in blueberry, grapes, mulberry, etc., is well documented to exhibit potent neuroprotective activity against different ND by mitochondria modulation approach. Mitochondrial function impairment is the most common etiology and pathological process in various neurodegenerative disorders, viz. Alzheimer’s disease, Parkinson’s disease, Huntington’s disease and amyotrophic lateral sclerosis. Nowadays these ND associated with mitochondrial dysfunction have become a major threat to public health as well as health care systems in terms of financial burden. Currently available therapies for ND are limited to symptomatic cures and have inevitable toxic effects. Therefore, there is a strict requirement for a safe and highly effective drug treatment developed from natural compounds. The current review provides updated information about the potential of resveratrol to target mitochondria in the treatment of ND. Frontiers Media S.A. 2022-09-16 /pmc/articles/PMC9523540/ /pubmed/36188541 http://dx.doi.org/10.3389/fphar.2022.922232 Text en Copyright © 2022 Yadav, Yadav, Khan, Singh and Verma. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Yadav, Ekta
Yadav, Pankajkumar
Khan, Mohd Masih Uzzaman
Singh, HariOm
Verma, Amita
Resveratrol: A potential therapeutic natural polyphenol for neurodegenerative diseases associated with mitochondrial dysfunction
title Resveratrol: A potential therapeutic natural polyphenol for neurodegenerative diseases associated with mitochondrial dysfunction
title_full Resveratrol: A potential therapeutic natural polyphenol for neurodegenerative diseases associated with mitochondrial dysfunction
title_fullStr Resveratrol: A potential therapeutic natural polyphenol for neurodegenerative diseases associated with mitochondrial dysfunction
title_full_unstemmed Resveratrol: A potential therapeutic natural polyphenol for neurodegenerative diseases associated with mitochondrial dysfunction
title_short Resveratrol: A potential therapeutic natural polyphenol for neurodegenerative diseases associated with mitochondrial dysfunction
title_sort resveratrol: a potential therapeutic natural polyphenol for neurodegenerative diseases associated with mitochondrial dysfunction
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9523540/
https://www.ncbi.nlm.nih.gov/pubmed/36188541
http://dx.doi.org/10.3389/fphar.2022.922232
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