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A multi-functional zwitterionic hydrogel with unique micro-structure, high elasticity and low modulus
Owing to their tissue-like softness and low modulus, hydrogels minimize the mechanical mismatch with biological tissues and have received wide attention as biomaterials. However, the development of soft hydrogels is often limited by their brittleness. Here, an ultra-soft and tough hydrogel based on...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9523660/ https://www.ncbi.nlm.nih.gov/pubmed/36320261 http://dx.doi.org/10.1039/d2ra04915e |
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author | Wang, Yueyang Wang, Qiao Hu, Xiaosai He, Dan Zhao, Juan Sun, Guoxing |
author_facet | Wang, Yueyang Wang, Qiao Hu, Xiaosai He, Dan Zhao, Juan Sun, Guoxing |
author_sort | Wang, Yueyang |
collection | PubMed |
description | Owing to their tissue-like softness and low modulus, hydrogels minimize the mechanical mismatch with biological tissues and have received wide attention as biomaterials. However, the development of soft hydrogels is often limited by their brittleness. Here, an ultra-soft and tough hydrogel based on zwitterionic poly(sulfobetaine methacrylate) (PSBMA) was designed and successfully prepared. The obtained PSBMA hydrogel exhibits a unique spike-like micro-structure, low modulus, good stretchability and excellent compressive elasticity, due to the formation of a dual-crosslinking structure. The obtained hydrogel also possesses self-healing properties and electromechanical responses to tensile and compressive deformations. Moreover, the hydrogel has good compatibility attributed to its outstanding anti-protein-adsorption properties. |
format | Online Article Text |
id | pubmed-9523660 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | The Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-95236602022-10-31 A multi-functional zwitterionic hydrogel with unique micro-structure, high elasticity and low modulus Wang, Yueyang Wang, Qiao Hu, Xiaosai He, Dan Zhao, Juan Sun, Guoxing RSC Adv Chemistry Owing to their tissue-like softness and low modulus, hydrogels minimize the mechanical mismatch with biological tissues and have received wide attention as biomaterials. However, the development of soft hydrogels is often limited by their brittleness. Here, an ultra-soft and tough hydrogel based on zwitterionic poly(sulfobetaine methacrylate) (PSBMA) was designed and successfully prepared. The obtained PSBMA hydrogel exhibits a unique spike-like micro-structure, low modulus, good stretchability and excellent compressive elasticity, due to the formation of a dual-crosslinking structure. The obtained hydrogel also possesses self-healing properties and electromechanical responses to tensile and compressive deformations. Moreover, the hydrogel has good compatibility attributed to its outstanding anti-protein-adsorption properties. The Royal Society of Chemistry 2022-09-30 /pmc/articles/PMC9523660/ /pubmed/36320261 http://dx.doi.org/10.1039/d2ra04915e Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/ |
spellingShingle | Chemistry Wang, Yueyang Wang, Qiao Hu, Xiaosai He, Dan Zhao, Juan Sun, Guoxing A multi-functional zwitterionic hydrogel with unique micro-structure, high elasticity and low modulus |
title | A multi-functional zwitterionic hydrogel with unique micro-structure, high elasticity and low modulus |
title_full | A multi-functional zwitterionic hydrogel with unique micro-structure, high elasticity and low modulus |
title_fullStr | A multi-functional zwitterionic hydrogel with unique micro-structure, high elasticity and low modulus |
title_full_unstemmed | A multi-functional zwitterionic hydrogel with unique micro-structure, high elasticity and low modulus |
title_short | A multi-functional zwitterionic hydrogel with unique micro-structure, high elasticity and low modulus |
title_sort | multi-functional zwitterionic hydrogel with unique micro-structure, high elasticity and low modulus |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9523660/ https://www.ncbi.nlm.nih.gov/pubmed/36320261 http://dx.doi.org/10.1039/d2ra04915e |
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