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Phosphoproteomics reveals that cinobufotalin promotes intrahepatic cholangiocarcinoma cell apoptosis by activating the ATM/CHK2/p53 signaling pathway

Intrahepatic cholangiocarcinoma (ICC) is a malignant tumor that originates from bile duct’s epithelial cells and is usually characterized by insidious symptoms and poor prognosis. Cinobufotalin (CB), an active ingredient obtained from the Traditional Chinese Medicine ChanSu, is purported to exhibit...

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Detalles Bibliográficos
Autores principales:	Xia, Zhili, Li, Minzhen, Hu, Meng, Lin, Yanyan, Atteh, Lawrence Lawer, Fu, Wenkang, Gao, Long, Bai, Mingzhen, Huang, Chongfei, Yue, Ping, Liu, Yu, Meng, Wenbo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9523695/ https://www.ncbi.nlm.nih.gov/pubmed/36185307 http://dx.doi.org/10.3389/fonc.2022.982961

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