An intranasal stringent response vaccine targeting dendritic cells as a novel adjunctive therapy against tuberculosis

Lengthy tuberculosis (TB) treatment is required to overcome the ability of a subpopulation of persistent Mycobacterium tuberculosis (Mtb) to remain in a non-replicating, antibiotic-tolerant state characterized by metabolic remodeling, including induction of the Rel(Mtb)-mediated stringent response....

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Detalles Bibliográficos
Autores principales: Karanika, Styliani, Gordy, James T., Neupane, Pranita, Karantanos, Theodoros, Ruelas Castillo, Jennie, Quijada, Darla, Comstock, Kaitlyn, Sandhu, Avinaash K., Kapoor, Aakanksha R., Hui, Yinan, Ayeh, Samuel K., Tasneen, Rokeya, Krug, Stefanie, Danchik, Carina, Wang, Tianyin, Schill, Courtney, Markham, Richard B., Karakousis, Petros C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9523784/
https://www.ncbi.nlm.nih.gov/pubmed/36189260
http://dx.doi.org/10.3389/fimmu.2022.972266

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