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The role of colonic motility in low anterior resection syndrome
Low anterior resection syndrome (LARS) describes the symptoms and experiences of bowel dysfunction experienced by patients after rectal cancer surgery. LARS is a complex and multifactorial syndrome exacerbated by factors such as low anastomotic height, defunctioning of the colon and neorectum, and r...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9523793/ https://www.ncbi.nlm.nih.gov/pubmed/36185226 http://dx.doi.org/10.3389/fonc.2022.975386 |
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author | Varghese, Chris Wells, Cameron I. Bissett, Ian P. O’Grady, Gregory Keane, Celia |
author_facet | Varghese, Chris Wells, Cameron I. Bissett, Ian P. O’Grady, Gregory Keane, Celia |
author_sort | Varghese, Chris |
collection | PubMed |
description | Low anterior resection syndrome (LARS) describes the symptoms and experiences of bowel dysfunction experienced by patients after rectal cancer surgery. LARS is a complex and multifactorial syndrome exacerbated by factors such as low anastomotic height, defunctioning of the colon and neorectum, and radiotherapy. There has recently been growing awareness and understanding regarding the role of colonic motility as a contributing mechanism for LARS. It is well established that rectosigmoid motility serves an important role in coordinating rectal filling and maintaining continence. Resection of the rectosigmoid may therefore contribute to LARS through altered distal colonic and neorectal motility. This review evaluates the role of colonic motility within the broader pathophysiology of LARS and outlines future directions of research needed to enable targeted therapy for specific LARS phenotypes. |
format | Online Article Text |
id | pubmed-9523793 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95237932022-10-01 The role of colonic motility in low anterior resection syndrome Varghese, Chris Wells, Cameron I. Bissett, Ian P. O’Grady, Gregory Keane, Celia Front Oncol Oncology Low anterior resection syndrome (LARS) describes the symptoms and experiences of bowel dysfunction experienced by patients after rectal cancer surgery. LARS is a complex and multifactorial syndrome exacerbated by factors such as low anastomotic height, defunctioning of the colon and neorectum, and radiotherapy. There has recently been growing awareness and understanding regarding the role of colonic motility as a contributing mechanism for LARS. It is well established that rectosigmoid motility serves an important role in coordinating rectal filling and maintaining continence. Resection of the rectosigmoid may therefore contribute to LARS through altered distal colonic and neorectal motility. This review evaluates the role of colonic motility within the broader pathophysiology of LARS and outlines future directions of research needed to enable targeted therapy for specific LARS phenotypes. Frontiers Media S.A. 2022-09-16 /pmc/articles/PMC9523793/ /pubmed/36185226 http://dx.doi.org/10.3389/fonc.2022.975386 Text en Copyright © 2022 Varghese, Wells, Bissett, O’Grady and Keane https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Varghese, Chris Wells, Cameron I. Bissett, Ian P. O’Grady, Gregory Keane, Celia The role of colonic motility in low anterior resection syndrome |
title | The role of colonic motility in low anterior resection syndrome |
title_full | The role of colonic motility in low anterior resection syndrome |
title_fullStr | The role of colonic motility in low anterior resection syndrome |
title_full_unstemmed | The role of colonic motility in low anterior resection syndrome |
title_short | The role of colonic motility in low anterior resection syndrome |
title_sort | role of colonic motility in low anterior resection syndrome |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9523793/ https://www.ncbi.nlm.nih.gov/pubmed/36185226 http://dx.doi.org/10.3389/fonc.2022.975386 |
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