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The role of colonic motility in low anterior resection syndrome

Low anterior resection syndrome (LARS) describes the symptoms and experiences of bowel dysfunction experienced by patients after rectal cancer surgery. LARS is a complex and multifactorial syndrome exacerbated by factors such as low anastomotic height, defunctioning of the colon and neorectum, and r...

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Autores principales: Varghese, Chris, Wells, Cameron I., Bissett, Ian P., O’Grady, Gregory, Keane, Celia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9523793/
https://www.ncbi.nlm.nih.gov/pubmed/36185226
http://dx.doi.org/10.3389/fonc.2022.975386
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author Varghese, Chris
Wells, Cameron I.
Bissett, Ian P.
O’Grady, Gregory
Keane, Celia
author_facet Varghese, Chris
Wells, Cameron I.
Bissett, Ian P.
O’Grady, Gregory
Keane, Celia
author_sort Varghese, Chris
collection PubMed
description Low anterior resection syndrome (LARS) describes the symptoms and experiences of bowel dysfunction experienced by patients after rectal cancer surgery. LARS is a complex and multifactorial syndrome exacerbated by factors such as low anastomotic height, defunctioning of the colon and neorectum, and radiotherapy. There has recently been growing awareness and understanding regarding the role of colonic motility as a contributing mechanism for LARS. It is well established that rectosigmoid motility serves an important role in coordinating rectal filling and maintaining continence. Resection of the rectosigmoid may therefore contribute to LARS through altered distal colonic and neorectal motility. This review evaluates the role of colonic motility within the broader pathophysiology of LARS and outlines future directions of research needed to enable targeted therapy for specific LARS phenotypes.
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spelling pubmed-95237932022-10-01 The role of colonic motility in low anterior resection syndrome Varghese, Chris Wells, Cameron I. Bissett, Ian P. O’Grady, Gregory Keane, Celia Front Oncol Oncology Low anterior resection syndrome (LARS) describes the symptoms and experiences of bowel dysfunction experienced by patients after rectal cancer surgery. LARS is a complex and multifactorial syndrome exacerbated by factors such as low anastomotic height, defunctioning of the colon and neorectum, and radiotherapy. There has recently been growing awareness and understanding regarding the role of colonic motility as a contributing mechanism for LARS. It is well established that rectosigmoid motility serves an important role in coordinating rectal filling and maintaining continence. Resection of the rectosigmoid may therefore contribute to LARS through altered distal colonic and neorectal motility. This review evaluates the role of colonic motility within the broader pathophysiology of LARS and outlines future directions of research needed to enable targeted therapy for specific LARS phenotypes. Frontiers Media S.A. 2022-09-16 /pmc/articles/PMC9523793/ /pubmed/36185226 http://dx.doi.org/10.3389/fonc.2022.975386 Text en Copyright © 2022 Varghese, Wells, Bissett, O’Grady and Keane https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Varghese, Chris
Wells, Cameron I.
Bissett, Ian P.
O’Grady, Gregory
Keane, Celia
The role of colonic motility in low anterior resection syndrome
title The role of colonic motility in low anterior resection syndrome
title_full The role of colonic motility in low anterior resection syndrome
title_fullStr The role of colonic motility in low anterior resection syndrome
title_full_unstemmed The role of colonic motility in low anterior resection syndrome
title_short The role of colonic motility in low anterior resection syndrome
title_sort role of colonic motility in low anterior resection syndrome
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9523793/
https://www.ncbi.nlm.nih.gov/pubmed/36185226
http://dx.doi.org/10.3389/fonc.2022.975386
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