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Fibroblast growth factor 21 is associated with widening QRS complex and prolonged corrected QT interval in patients with stable angina
BACKGROUND: Fibroblast growth factor 21 (FGF21) is produced by cardiac cells, may acts in an autocrine manner, and was suggested to has a cardioprotective role in atherosclerosis. Wide QRS complex and heart rate-corrected QT interval (QTc interval) prolongation are associated to dangerous ventricula...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9523937/ https://www.ncbi.nlm.nih.gov/pubmed/36180826 http://dx.doi.org/10.1186/s12872-022-02868-3 |
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author | Hung, Wei-Chin Yu, Teng-Hung Wang, Chao-Ping Hsu, Chia-Chang Lu, Yung-Chuan Wei, Ching-Ting Chung, Fu-Mei Lee, Yau-Jiunn Wu, Cheng-Ching Tang, Wei-Hua |
author_facet | Hung, Wei-Chin Yu, Teng-Hung Wang, Chao-Ping Hsu, Chia-Chang Lu, Yung-Chuan Wei, Ching-Ting Chung, Fu-Mei Lee, Yau-Jiunn Wu, Cheng-Ching Tang, Wei-Hua |
author_sort | Hung, Wei-Chin |
collection | PubMed |
description | BACKGROUND: Fibroblast growth factor 21 (FGF21) is produced by cardiac cells, may acts in an autocrine manner, and was suggested to has a cardioprotective role in atherosclerosis. Wide QRS complex and heart rate-corrected QT interval (QTc interval) prolongation are associated to dangerous ventricular arrhythmias and cardiovascular disease mortality. Yet, the role of FGF21 in cardiac arrhythmia has never been studied. The aim of the study was to investigate the relationship between plasma FGF21 and the QRS duration and QTc interval in patients with stable angina. METHODS: Three hundred twenty-one consecutive stable angina patients were investigated. Plasma FGF21 was measured through ELISA, and each subject underwent 12-lead electrocardiography. RESULTS: FGF21 plasma levels were positively associated with the QRS duration (β = 0.190, P = 0.001) and QTc interval (β = 0.277, P < 0.0001). With increasing FGF21 tertiles, the patients had higher frequencies of wide QRS complex and prolonged QTc interval. After adjusting for patients’ anthropometric parameters, the corresponding odd ratios (ORs) for wide QRS complex of the medium and high of FGF21 versus the low of FGF21 were 1.39 (95% CI 0.51–3.90) and 4.41 (95% CI 1.84–11.59), respectively, and p for trend was 0.001. Furthermore, multiple logistic regression analysis also showed the corresponding odd ratios (ORs) for prolonged QTc interval of the medium and high of FGF21 versus the low of FGF21 were 1.02 (95% CI 0.53–1.78) and 1.93 (95% CI 1.04–3.60) respectively with the p for trend of 0.037. In addition, age- and sex-adjusted FGF21 levels were positively associated with fasting glucose, HbA1c, creatinine, and adiponectin, but negatively associated with albumin, and the estimated glomerular filtration rate. CONCLUSIONS: This study indicates that plasma FGF21 is associated with wide QRS complex and prolonged corrected QT interval in stable angina patients, further study is required to investigate the role of plasma FGF21 for the underlying pathogenesis. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12872-022-02868-3. |
format | Online Article Text |
id | pubmed-9523937 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-95239372022-10-01 Fibroblast growth factor 21 is associated with widening QRS complex and prolonged corrected QT interval in patients with stable angina Hung, Wei-Chin Yu, Teng-Hung Wang, Chao-Ping Hsu, Chia-Chang Lu, Yung-Chuan Wei, Ching-Ting Chung, Fu-Mei Lee, Yau-Jiunn Wu, Cheng-Ching Tang, Wei-Hua BMC Cardiovasc Disord Research BACKGROUND: Fibroblast growth factor 21 (FGF21) is produced by cardiac cells, may acts in an autocrine manner, and was suggested to has a cardioprotective role in atherosclerosis. Wide QRS complex and heart rate-corrected QT interval (QTc interval) prolongation are associated to dangerous ventricular arrhythmias and cardiovascular disease mortality. Yet, the role of FGF21 in cardiac arrhythmia has never been studied. The aim of the study was to investigate the relationship between plasma FGF21 and the QRS duration and QTc interval in patients with stable angina. METHODS: Three hundred twenty-one consecutive stable angina patients were investigated. Plasma FGF21 was measured through ELISA, and each subject underwent 12-lead electrocardiography. RESULTS: FGF21 plasma levels were positively associated with the QRS duration (β = 0.190, P = 0.001) and QTc interval (β = 0.277, P < 0.0001). With increasing FGF21 tertiles, the patients had higher frequencies of wide QRS complex and prolonged QTc interval. After adjusting for patients’ anthropometric parameters, the corresponding odd ratios (ORs) for wide QRS complex of the medium and high of FGF21 versus the low of FGF21 were 1.39 (95% CI 0.51–3.90) and 4.41 (95% CI 1.84–11.59), respectively, and p for trend was 0.001. Furthermore, multiple logistic regression analysis also showed the corresponding odd ratios (ORs) for prolonged QTc interval of the medium and high of FGF21 versus the low of FGF21 were 1.02 (95% CI 0.53–1.78) and 1.93 (95% CI 1.04–3.60) respectively with the p for trend of 0.037. In addition, age- and sex-adjusted FGF21 levels were positively associated with fasting glucose, HbA1c, creatinine, and adiponectin, but negatively associated with albumin, and the estimated glomerular filtration rate. CONCLUSIONS: This study indicates that plasma FGF21 is associated with wide QRS complex and prolonged corrected QT interval in stable angina patients, further study is required to investigate the role of plasma FGF21 for the underlying pathogenesis. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12872-022-02868-3. BioMed Central 2022-09-30 /pmc/articles/PMC9523937/ /pubmed/36180826 http://dx.doi.org/10.1186/s12872-022-02868-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Hung, Wei-Chin Yu, Teng-Hung Wang, Chao-Ping Hsu, Chia-Chang Lu, Yung-Chuan Wei, Ching-Ting Chung, Fu-Mei Lee, Yau-Jiunn Wu, Cheng-Ching Tang, Wei-Hua Fibroblast growth factor 21 is associated with widening QRS complex and prolonged corrected QT interval in patients with stable angina |
title | Fibroblast growth factor 21 is associated with widening QRS complex and prolonged corrected QT interval in patients with stable angina |
title_full | Fibroblast growth factor 21 is associated with widening QRS complex and prolonged corrected QT interval in patients with stable angina |
title_fullStr | Fibroblast growth factor 21 is associated with widening QRS complex and prolonged corrected QT interval in patients with stable angina |
title_full_unstemmed | Fibroblast growth factor 21 is associated with widening QRS complex and prolonged corrected QT interval in patients with stable angina |
title_short | Fibroblast growth factor 21 is associated with widening QRS complex and prolonged corrected QT interval in patients with stable angina |
title_sort | fibroblast growth factor 21 is associated with widening qrs complex and prolonged corrected qt interval in patients with stable angina |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9523937/ https://www.ncbi.nlm.nih.gov/pubmed/36180826 http://dx.doi.org/10.1186/s12872-022-02868-3 |
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