Inhibition of CISD2 promotes ferroptosis through ferritinophagy-mediated ferritin turnover and regulation of p62–Keap1–NRF2 pathway

BACKGROUND: CDGSH iron sulfur domain 2 (CISD2) is an iron–sulfur protein with a [2Fe–2S] cluster, which is critical for cell proliferation and iron homeostasis. It has been demonstrated that aberrant expression of CISD2 is associated with the progression of multiple cancers. However, the underlying...

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Detalles Bibliográficos
Autores principales: Li, Yanchun, Xu, Bing, Ren, Xueying, Wang, Luyang, Xu, Yaqing, Zhao, Yefeng, Yang, Chen, Yuan, Chen, Li, Huanjuan, Tong, Xiangmin, Wang, Ying, Du, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9523958/
https://www.ncbi.nlm.nih.gov/pubmed/36180832
http://dx.doi.org/10.1186/s11658-022-00383-z

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