A conserved transcriptional fingerprint of multi-neurotransmitter neurons necessary for social behavior

BACKGROUND: An essential determinant of a neuron’s functionality is its neurotransmitter phenotype. We previously identified a defined subpopulation of cholinergic neurons required for social orienting behavior in zebrafish. RESULTS: We transcriptionally profiled these neurons and discovered that th...

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Detalles Bibliográficos
Autores principales: Ncube, Denver, Tallafuss, Alexandra, Serafin, Jen, Bruckner, Joseph, Farnsworth, Dylan R., Miller, Adam C., Eisen, Judith S., Washbourne, Philip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9523972/
https://www.ncbi.nlm.nih.gov/pubmed/36175871
http://dx.doi.org/10.1186/s12864-022-08879-w
Descripción
Sumario:BACKGROUND: An essential determinant of a neuron’s functionality is its neurotransmitter phenotype. We previously identified a defined subpopulation of cholinergic neurons required for social orienting behavior in zebrafish. RESULTS: We transcriptionally profiled these neurons and discovered that they are capable of synthesizing both acetylcholine and GABA. We also established a constellation of transcription factors and neurotransmitter markers that can be used as a “transcriptomic fingerprint” to recognize a homologous neuronal population in another vertebrate. CONCLUSION: Our results suggest that this transcriptomic fingerprint and the cholinergic-GABAergic neuronal subtype that it defines are evolutionarily conserved. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12864-022-08879-w.

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