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TRIM3 and TRIM16 as potential tumor suppressors in breast cancer patients

OBJECTIVE: Breast cancer is the leading cause of death among women in many countries. Numerous factors serve as oncogenes or tumor suppressors in breast cancer. The large family of Tripartite-motif (TRIM) proteins with ~ 80 members has drawn attention for their role in cancer. TRIM3 and TRIM16 have...

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Autores principales: Roshanazadeh, Mohammad Reza, Adelipour, Maryam, Sanaei, Arash, Chenane, Hadi, Rashidi, Mojtaba
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9523982/
https://www.ncbi.nlm.nih.gov/pubmed/36180926
http://dx.doi.org/10.1186/s13104-022-06193-y
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author Roshanazadeh, Mohammad Reza
Adelipour, Maryam
Sanaei, Arash
Chenane, Hadi
Rashidi, Mojtaba
author_facet Roshanazadeh, Mohammad Reza
Adelipour, Maryam
Sanaei, Arash
Chenane, Hadi
Rashidi, Mojtaba
author_sort Roshanazadeh, Mohammad Reza
collection PubMed
description OBJECTIVE: Breast cancer is the leading cause of death among women in many countries. Numerous factors serve as oncogenes or tumor suppressors in breast cancer. The large family of Tripartite-motif (TRIM) proteins with ~ 80 members has drawn attention for their role in cancer. TRIM3 and TRIM16 have shown suppressive activity in different cancers. This study aimed to evaluate the expression of TRIM3 and TRIM16 in cancerous and normal breast samples and to investigate their association with different clinical and pathological parameters. RESULTS: qRT-PCR was utilized to determine the gene expression of TRIM3 and TRIM16. The expression of TRIM3 and TRIM16 genes in tumor samples were significantly reduced to 0.45 and 0.29 fold, respectively. TRIM3 and TRIM16 genes expression were both positively correlated with the invasion of breast cancer. TRIM3 gene expression was associated with tumors’ histological grade. However, no significant association was found between the expression of the genes and tumor size, stage and necrosis. The expression of TRIM3 and TRIM16 are significantly reduced in breast cancer tissues. Besides, the expression of both TRIM3 and TRIM16 genes significantly plummet in lymphatic/vascular and perineural invasive samples. Hence, we suggest a potential tumor suppressor role for TRIM3 and TRIM16 in breast cancer.
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spelling pubmed-95239822022-10-01 TRIM3 and TRIM16 as potential tumor suppressors in breast cancer patients Roshanazadeh, Mohammad Reza Adelipour, Maryam Sanaei, Arash Chenane, Hadi Rashidi, Mojtaba BMC Res Notes Research Note OBJECTIVE: Breast cancer is the leading cause of death among women in many countries. Numerous factors serve as oncogenes or tumor suppressors in breast cancer. The large family of Tripartite-motif (TRIM) proteins with ~ 80 members has drawn attention for their role in cancer. TRIM3 and TRIM16 have shown suppressive activity in different cancers. This study aimed to evaluate the expression of TRIM3 and TRIM16 in cancerous and normal breast samples and to investigate their association with different clinical and pathological parameters. RESULTS: qRT-PCR was utilized to determine the gene expression of TRIM3 and TRIM16. The expression of TRIM3 and TRIM16 genes in tumor samples were significantly reduced to 0.45 and 0.29 fold, respectively. TRIM3 and TRIM16 genes expression were both positively correlated with the invasion of breast cancer. TRIM3 gene expression was associated with tumors’ histological grade. However, no significant association was found between the expression of the genes and tumor size, stage and necrosis. The expression of TRIM3 and TRIM16 are significantly reduced in breast cancer tissues. Besides, the expression of both TRIM3 and TRIM16 genes significantly plummet in lymphatic/vascular and perineural invasive samples. Hence, we suggest a potential tumor suppressor role for TRIM3 and TRIM16 in breast cancer. BioMed Central 2022-09-30 /pmc/articles/PMC9523982/ /pubmed/36180926 http://dx.doi.org/10.1186/s13104-022-06193-y Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Note
Roshanazadeh, Mohammad Reza
Adelipour, Maryam
Sanaei, Arash
Chenane, Hadi
Rashidi, Mojtaba
TRIM3 and TRIM16 as potential tumor suppressors in breast cancer patients
title TRIM3 and TRIM16 as potential tumor suppressors in breast cancer patients
title_full TRIM3 and TRIM16 as potential tumor suppressors in breast cancer patients
title_fullStr TRIM3 and TRIM16 as potential tumor suppressors in breast cancer patients
title_full_unstemmed TRIM3 and TRIM16 as potential tumor suppressors in breast cancer patients
title_short TRIM3 and TRIM16 as potential tumor suppressors in breast cancer patients
title_sort trim3 and trim16 as potential tumor suppressors in breast cancer patients
topic Research Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9523982/
https://www.ncbi.nlm.nih.gov/pubmed/36180926
http://dx.doi.org/10.1186/s13104-022-06193-y
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