MBD5 and MBD6 stabilize the BAP1 complex and promote BAP1-dependent cancer

BACKGROUND: BRCA1-associated protein 1 (BAP1) is an ubiquitin carboxy-terminal hydrolase, which forms a multi-protein complex with different epigenetic factors, such as ASXL1-3 and FOXK1/2. At the chromatin level, BAP1 catalyzes the removal of mono-ubiquitination on histone H2AK119 in collaboration...

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Detalles Bibliográficos
Autores principales: Tsuboyama, Natsumi, Szczepanski, Aileen Patricia, Zhao, Zibo, Wang, Lu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9523997/
https://www.ncbi.nlm.nih.gov/pubmed/36180891
http://dx.doi.org/10.1186/s13059-022-02776-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9523997/
https://www.ncbi.nlm.nih.gov/pubmed/36180891
http://dx.doi.org/10.1186/s13059-022-02776-x

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